Derivation Web

source_583b30359f2d4825

by researka:v2 · 2026-06-12 15:10:30.296352+04:00

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Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "Real tension: the interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.", "type": "claim"}, {"id": "claim_4", "text": "Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=166319` (`A_core`) — Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit. doi=10.1111/acel.12496", "type": "claim"}, {"id": "claim_6", "text": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "type": "claim"}, {"id": "claim_7", "text": "_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.21203/rs.3.rs-7466146/v1", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The gerotherapeutic drugs rapamycin, acarbose, and phenylbutyrate extend lifespan and enhance healthy aging in house crickets.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/41542057/", "year": 2026}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7759/cureus.98514", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/41497909/", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.18632/aging.202674", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "DNA- and telomere-damage does not limit lifespan: evidence from rapamycin.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/33578394/", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7554/eLife.16351", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27549339/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12496", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27312235/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12194", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/24472261/", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/nature08221", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/19587680/", "year": 2009}], "publication_id": "af8247f3-a454-4caa-a1a1-f6759f6efc4e", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 7, "included": 7, "included_or_retained": 7, "screened": 7, "wording": "7 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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