source · application/json
source_58ffe0df815a4032
sha256 bd48da93308f71e15a42a443998ba0c620d905e402c3ddc7bfe547f89da34a6a
by researka:v2 · 2026-05-24 11:44:00.981439+04:00
{"content_hash": null, "edges": [{"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_1", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_2", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_3", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_4", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_5", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_6", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_7", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_8", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_9", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_10", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_11", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_12", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_13", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_14", "type": "contains_claim"}, {"from": "3b113aa9-b186-46fc-b8f4-57f813513544", "to": "claim_15", "type": "contains_claim"}], "nodes": [{"id": "3b113aa9-b186-46fc-b8f4-57f813513544", "title": "Exercise signals are endpoint-specific, not uniformly generalizable", "type": "publication"}, {"id": "claim_1", "text": "Source scope:** 16 A/B-bound receipts across 10 evidence sources; 12 total references in the source bundle. Two source-bundle entries are corpus-context references for breadth, not thesis proof; schema labels still use primary/review only.", "type": "claim"}, {"id": "claim_2", "text": "The exercise corpus in this run supports a broader alpha signal: exercise effects are endpoint- and context-specific rather than uniformly generalizable. The strongest bound receipts span inflammatory markers, exercise capacity and mortality, tumor-model response, angiogenesis biomarkers, muscle-protein synthesis, peripheral oxygen extraction, dietary inflammatory index, and NO/exercise muscle effects.", "type": "claim"}, {"id": "claim_3", "text": "The common story treats exercise as a single beneficial geroscience intervention. This evidence map says the more useful signal is specificity: different populations, endpoints, and mechanisms move differently, so the publishable claim is not “exercise works,” but “exercise signals need endpoint- and context-specific interpretation.”", "type": "claim"}, {"id": "claim_4", "text": "`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=12573` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`", "type": "claim"}, {"id": "claim_6", "text": "`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`", "type": "claim"}, {"id": "claim_7", "text": "`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`", "type": "claim"}, {"id": "claim_8", "text": "`fact_id=34200` (`A_core`) — NO-donor treatment with isosorbide dinitrate for 6 wk, in combination with voluntary exercise for 3 wk, increased muscle mass by 25% DOI `10.1152/ajpcell.00305.2011`", "type": "claim"}, {"id": "claim_9", "text": "2. Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development (2017). DOI `10.1158/0008-5472.can-16-3125` — `primary`", "type": "claim"}, {"id": "claim_10", "text": "10. Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice (2012). DOI `10.1152/ajpcell.00305.2011` — `primary`", "type": "claim"}, {"id": "claim_11", "text": "Do not treat exercise as one generic anti-aging lever in review or trial design. Split claims by endpoint family before making a broad conclusion: inflammation, tumor biology, vascular oxygenation, muscle synthesis, mortality/exercise capacity, and diet-linked biomarker changes are different evidence lanes.", "type": "claim"}, {"id": "claim_12", "text": "The topic is heterogeneous, so the memo should guide subtopic extraction rather than support one pooled treatment-effect claim.", "type": "claim"}, {"id": "claim_13", "text": "No A_core/B_context counter-evidence was classified in this run, but the heterogeneity of endpoints is itself a constraint on broad claims.", "type": "claim"}, {"id": "claim_14", "text": "Re-run counter-evidence search against each child topic so “no counter-evidence found” is not confused with proof of absence.", "type": "claim"}, {"id": "claim_15", "text": "Suggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpendo.00600.2013", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/0008-5472.can-16-3125", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "type": "source", "url": null, "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1161/hypertensionaha.114.03510", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1940-6207.capr-20-0188", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "type": "source", "url": null, "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1055-9965.epi-13-0337", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "type": "source", "url": null, "year": 2013}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/japplphysiol.01110.2016", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Blood pressure and calf muscle oxygen extraction during plantar flexion exercise in peripheral artery disease", "type": "source", "url": null, "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/0008-5472.can-16-0399", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Dietary Weight Loss and Exercise Effects on Serum Biomarkers of Angiogenesis in Overweight Postmenopausal Women: A Randomized Controlled Trial", "type": "source", "url": null, "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1096/fj.12-224006", "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Abnormal protein turnover and anabolic resistance to exercise in sarcopenic obesity", "type": "source", "url": null, "year": 2013}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1940-6207.capr-20-0181", "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Changes in Dietary Inflammatory Index Patterns with Weight Loss in Women: A Randomized Controlled Trial", "type": "source", "url": null, "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpcell.00305.2011", "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Nitric oxide and voluntary exercise together promote quadriceps hypertrophy and increase vascular density in female 18-mo-old mice", "type": "source", "url": null, "year": 2012}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/14651858.cd009955.pub3", "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise training undertaken by people within 12 months of lung resection for non-small cell lung cancer", "type": "source", "url": null, "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/gerona/glab297", "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex", "type": "source", "url": null, "year": 2021}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Topic:** `exercise`", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Author:** Dom Lynch", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Version:** 1.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_16", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**License:** CC BY-NC 4.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_17", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Suggested citation:** Dom Lynch. (2026). Exercise signals are endpoint-specific, not uniformly generalizable. ReseaRka Evidence Index. Version 1.0.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_18", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Run:** `exercise-evidence-2026-05-16T18-12-38Z`", "type": "source", "url": null, "year": null}], "publication_id": "3b113aa9-b186-46fc-b8f4-57f813513544", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 12, "included": 12, "included_or_retained": 12, "screened": 12, "wording": "12 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}
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{
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}