Derivation Web

source_590aa239c1884d56

by researka:v2 · 2026-06-27 18:17:40.110806+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeted activation of Nrf2 via sulforaphane-loaded exosomes attenuated azoospermic condition in the rat model,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Protective Effect of Sulforaphane on Dextran Sulfate Sodium-Induced Colitis Depends on Gut Microbial and Nrf2-Related Mechanism,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of dietary phytochemicals on nuclear factor erythroid 2-related factor 2 (Nrf2) activation: a systematic review of human intervention trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Sulforaphane attenuates phosgene-induced acute lung injury via the Nrf2-HO-1/NQO1 pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Stretch Causes Cell Stress and the Downregulation of Nrf2 in Primary Amnion Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane Alleviates Zearalenone-Induced Oxidative Stress in Bovine Mammary Epithelial Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Oxidative Stress in Keratoconus Is Evident in Tear Fluid and Stromal Cells and Alleviated in Cell Culture by Sulforaphane,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of azithromycin on lung oxidative injury and immune function in mice infected with Mycoplasma pneumoniae based on the Nrf2/ARE signaling pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age-Related Mitochondrial Impairment and Renal Injury Is Ameliorated by Sulforaphane via Activation of Transcription Factor NRF2,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Sulforaphane Treatment on Skeletal Muscle from Exhaustive Exercise-Induced Inflammation and Oxidative Stress Through the Nrf2/HO-1 Signaling Pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane alleviates hepatocyte pyroptosis via activating Nrf2-HO-1 signaling during septic acute liver injury,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Glucoraphanin on the Abundance of Nrf2 Regulated Genes Within Circulating Small Extracellular Vesicles: A Pilot Dietary Intervention,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane improves the bronchoprotective response in asthmatics through Nrf2-mediated gene pathways,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane-Enriched Broccoli Sprouts Pretreated by Pulsed Electric Fields Reduces Neuroinflammation and Ameliorates Scopolamine-Induced Amnesia in Mouse Brain through Its Antioxidant Ability via Nrf2-HO-1 Activation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 via stimulating the Akt/GSK-3ß/Fyn pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A proof-of-concept clinical study examining the NRF2 activator sulforaphane against neutrophilic airway inflammation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Lack of Effect of Oral Sulforaphane Administration on Nrf2 Expression in COPD: A Randomized, Double-Blind, Placebo Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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