Derivation Web

source_5acf6c7b4a664271

by researka:v2 · 2026-06-21 20:56:16.412858+04:00

{"contradictions": ["The conclusion is that NAD+ metabolism effects remains a bounded geroscience case: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "Signal-accounting note: biomarker-positive source-level findings are separated from clinical-endpoint mixed/null rows; biomarker elevation is not counted as clinical efficacy unless the mapped outcome class and endpoint support it.", "Tension-accounting note: disagreement counts are claim-level. Substantive tension still remains between biomarker-elevating studies and mixed/null clinical-endpoint studies across cognition, menopause, acute-care, so these contrasts are treated as unresolved evidence gaps.", "Ryu 2022: Nicotinamide riboside and caffeine partially restore diminished NAD availability but not altered energy metabolism in Alzheimer's disease: outcome=Contextual Adjacent Evidence; directness=indirect; tier=B2."], "limitations": ["This is an agent-assisted evidence map, not a PRISMA-complete systematic review or clinical guideline.", "It is not PROSPERO-registered and should not be read as medical advice.", "Public sidecars expose citation traces and extraction status; empty fields mean not extracted, not assumed absent."], "publication_id": "529fbc6c-66ad-49b5-910a-f2b076cb190c", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 19, "included": 19, "included_or_retained": 19, "screened": 19, "wording": "19 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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