Derivation Web

v0.1 · api
source · application/json

source_5c852f178d7e4caa

sha256 b274c583daf4d1e18fded8bb414726d3ace06ece02865e5edb6024e42a7423d0

by researka:v2 · 2026-06-07 09:05:14.697324+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "43509a3d-2c33-48fb-9e4f-c3802c27d437", "sources": [{"directness": "review-level", "doi": "10.1038/s41598-025-95735-y", "risk_of_bias": "not appraised in public sidecar", "study": "Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models"}, {"directness": "primary", "doi": "10.3389/fcvm.2021.712478", "risk_of_bias": "not appraised in public sidecar", "study": "Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol"}, {"directness": "review-level", "doi": "10.1186/s12868-025-00937-9", "risk_of_bias": "not appraised in public sidecar", "study": "A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models"}, {"directness": "primary", "doi": "10.3390/antiox14010039", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide Mononucleotide Restores NAD + Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells"}, {"directness": "primary", "doi": "10.3389/fmicb.2022.1084257", "risk_of_bias": "not appraised in public sidecar", "study": "Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota"}, {"directness": "primary", "doi": "10.3389/fragi.2026.1773667", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial"}, {"directness": "primary", "doi": "10.1038/s42255-025-01421-8", "risk_of_bias": "not appraised in public sidecar", "study": "The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans"}, {"directness": "primary", "doi": "10.1038/s42255-024-00997-x", "risk_of_bias": "not appraised in public sidecar", "study": "Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia"}, {"directness": "review-level", "doi": "10.1093/jn/nxab193", "risk_of_bias": "not appraised in public sidecar", "study": "NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults."}, {"directness": "review-level", "doi": "10.1002/jcsm.70142", "risk_of_bias": "not appraised in public sidecar", "study": "NAD<sup>+</sup> Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT."}, {"directness": "primary", "doi": "10.1126/sciadv.aea9014", "risk_of_bias": "not appraised in public sidecar", "study": "Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development"}, {"directness": "review-level", "doi": "10.1016/j.phrs.2026.108190", "risk_of_bias": "not appraised in public sidecar", "study": "Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach."}, {"directness": "primary", "doi": "10.3389/fimmu.2025.1579924", "risk_of_bias": "not appraised in public sidecar", "study": "Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review"}, {"directness": "review-level", "doi": "10.1016/j.eclinm.2025.103633", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial."}, {"directness": "primary", "doi": "10.1038/s41467-018-03421-7", "risk_of_bias": "not appraised in public sidecar", "study": "Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults"}, {"directness": "primary", "doi": "10.1016/j.celrep.2019.07.043", "risk_of_bias": "not appraised in public sidecar", "study": "Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1093/ageing/26.1.15", "risk_of_bias": "not appraised in public sidecar", "study": "Bohannon 1997"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "43509a3d-2c33-48fb-9e4f-c3802c27d437",
  "researka_submission_id": "c837148d-aec6-495a-b13b-68a84c2d262e",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/43509a3d-2c33-48fb-9e4f-c3802c27d437/sidecars/risk_of_bias.json"
}

view full chain →