Derivation Web

source_5d8e9b6aa0b2482b

by researka:v2 · 2026-06-27 00:22:52.034580+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6 -associated neurodegeneration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bridging expectations and science: a roadmap for the future of longevity interventions,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Mitochondrial Proteome Reveals Metabolic Tuning by Restricted Insulin Signaling to Promote Longevity in Caenorhabditis elegans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Molecular mechanisms of metformin action: From metabolic effects to lifespan extension and healthspan promotion,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Yeast Chronological Lifespan Model as a Tool for Screening Aging Interventions,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dendrobium officinale leaf extract extends the mean lifespan in Caenorhabditis elegans via the DAF-16/SOD-3 axis.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans , and replicative lifespan in S. cerevisiae",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The exceptional longevity of the naked mole‐rat may be explained by mitochondrial antioxidant defenses,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cesari 2009,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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