Derivation Web

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source_5fe4de6916cf4766

sha256 548617eca10b4f6f0ec06d9806db47a73adf5a42ac2629a30d48c085db3379bb

by researka:v2 · 2026-06-22 18:18:43.037138+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6", "sources": [{"directness": "primary", "doi": "10.1186/s12933-025-03013-y", "risk_of_bias": "not appraised in public sidecar", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction"}, {"directness": "primary", "doi": "10.1038/s41392-022-01257-8", "risk_of_bias": "not appraised in public sidecar", "study": "The sirtuin family in health and disease"}, {"directness": "primary", "doi": "10.3390/nu13113824", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of Dietary Modifications on Plasma Sirtuins 1, 3 and 5 in Older Overweight Individuals Undergoing 12-Weeks of Circuit Training"}, {"directness": "primary", "doi": "10.3389/fimmu.2022.925738", "risk_of_bias": "not appraised in public sidecar", "study": "p53/sirtuin 1/NF-κB Signaling Axis in Chronic Inflammation and Maladaptive Kidney Repair After Cisplatin Nephrotoxicity"}, {"directness": "primary", "doi": "10.3390/biom10101414", "risk_of_bias": "not appraised in public sidecar", "study": "Changes in the Systemic Expression of Sirtuin-1 and Oxidative Stress after Intravitreal Anti-Vascular Endothelial Growth Factor in Patients with Retinal Vein Occlusion"}, {"directness": "primary", "doi": "10.1186/s12903-025-06690-z", "risk_of_bias": "not appraised in public sidecar", "study": "Taurine, Sirtuin-1 and TNF- α levels in different aged adults with periodontitis: a pilot study"}, {"directness": "primary", "doi": "10.3390/antiox11040706", "risk_of_bias": "not appraised in public sidecar", "study": "Sirtuin 3 Dependent and Independent Effects of NAD + to Suppress Vascular Inflammation and Improve Endothelial Function in Mice"}, {"directness": "review-level", "doi": "10.1155/jdr/5528647", "risk_of_bias": "not appraised in public sidecar", "study": "Deciphering the Role of Sirtuin‐1 Gene Polymorphism in Diabetic Nephropathy: A Systematic Review and Meta‐Analysis"}, {"directness": "primary", "doi": "10.3892/mmr.2021.12400", "risk_of_bias": "not appraised in public sidecar", "study": "Sirtuin 2 knockdown inhibits cell proliferation and RAS/ERK signaling, and promotes cell apoptosis and cell cycle arrest in multiple myeloma"}, {"directness": "primary", "doi": "10.3390/cimb46080522", "risk_of_bias": "not appraised in public sidecar", "study": "The Role of Sirtuin-1 Isoforms in Regulating Mitochondrial Function"}, {"directness": "primary", "doi": "10.1038/s12276-021-00687-8", "risk_of_bias": "not appraised in public sidecar", "study": "Upregulating sirtuin 6 ameliorates glycolysis, EMT and distant metastasis of pancreatic adenocarcinoma with krüppel-like factor 10 deficiency"}, {"directness": "primary", "doi": "10.1186/s13006-020-00301-z", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of perinatal factors on sirtuin 3, 8-hydroxy-2′- deoxyguanosine, brain-derived neurotrophic factor and serotonin in cord blood and early breast milk: an observational study"}, {"directness": "primary", "doi": "10.1038/s41598-024-78576-z", "risk_of_bias": "not appraised in public sidecar", "study": "Evaluation of sirtuin 1 as a predictor of cardiovascular outcomes in diabetic patients with limb-threatening ischemia"}, {"directness": "primary", "doi": "10.3390/ijms21010295", "risk_of_bias": "not appraised in public sidecar", "study": "Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}
metadata
{
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  "researka_publication_id": "1c0cf558-f04c-47e1-912b-a4da95e9a2f6",
  "researka_submission_id": "4f855829-abe8-4044-a29f-b31e8d67be2f",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/1c0cf558-f04c-47e1-912b-a4da95e9a2f6/sidecars/risk_of_bias.json"
}

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