Derivation Web

source_600e58915f074d18

by researka:v2 · 2026-06-29 00:28:37.834944+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "82831700-7ed3-4b2a-87cf-b14d27b3ea02", "sources": [{"directness": "primary", "doi": "10.1038/s41531-024-00660-y", "risk_of_bias": "not appraised in public sidecar", "study": "G2019S selective LRRK2 kinase inhibitor abrogates mitochondrial DNA damage"}, {"directness": "primary", "doi": "10.3390/ijms232315197", "risk_of_bias": "not appraised in public sidecar", "study": "Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments"}, {"directness": "primary", "doi": "10.1183/23120541.00874-2025", "risk_of_bias": "not appraised in public sidecar", "study": "Airway microbial dysbiosis and oxidative mitochondrial DNA damage in the development of bronchopulmonary dysplasia"}, {"directness": "primary", "doi": "10.3390/ijms26136255", "risk_of_bias": "not appraised in public sidecar", "study": "Methods for Mitochondrial DNA Damage and Depletion in Immortalized Trabecular Meshwork Cells"}, {"directness": "primary", "doi": "10.1038/s41598-023-41190-6", "risk_of_bias": "not appraised in public sidecar", "study": "Integrative blood-based characterization of oxidative mitochondrial DNA damage variants implicates Mexican American’s metabolic risk for developing Alzheimer’s disease"}, {"directness": "primary", "doi": "10.1186/s41021-026-00360-4", "risk_of_bias": "not appraised in public sidecar", "study": "A PUFA-rich diet increases endogenous genotoxic stress and mitochondrial DNA damage in mice"}, {"directness": "primary", "doi": "10.1155/2022/3529499", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Treadmill Exercise on Mitochondrial DNA Damage and Cardiomyocyte Telomerase Activity in Aging Model Rats Based on Classical Apoptosis Signaling Pathway"}, {"directness": "primary", "doi": "10.1016/j.jbc.2026.111156", "risk_of_bias": "not appraised in public sidecar", "study": "F2,6BP restores mitochondrial genome integrity in Huntington’s disease"}, {"directness": "primary", "doi": "10.1093/cid/ciaa984", "risk_of_bias": "not appraised in public sidecar", "study": "Mitochondrial DNA Damage and Brain Aging in Human Immunodeficiency Virus"}, {"directness": "primary", "doi": "10.3390/biom15121706", "risk_of_bias": "not appraised in public sidecar", "study": "Mitochondrial DNA Damage and Histological Features in Liver Tissue of Azoxymethane-Treated Apex1 Haploinsufficient Mice"}, {"directness": "primary", "doi": "10.3390/cells9122579", "risk_of_bias": "not appraised in public sidecar", "study": "Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults"}, {"directness": "primary", "doi": "10.3390/ijms25137060", "risk_of_bias": "not appraised in public sidecar", "study": "Cancerous Conditions Accelerate the Aging of Skeletal Muscle via Mitochondrial DNA Damage"}, {"directness": "primary", "doi": "10.3389/fgene.2019.00311", "risk_of_bias": "not appraised in public sidecar", "study": "Mitochondrial DNA Damage Does Not Determine C. elegans Lifespan"}, {"directness": "primary", "doi": "10.1155/2013/157547", "risk_of_bias": "not appraised in public sidecar", "study": "Simultaneous Quantification of Mitochondrial DNA Damage and Copy Number in Circulating Blood: A Sensitive Approach to Systemic Oxidative Stress"}, {"directness": "primary", "doi": "10.3390/cells8121525", "risk_of_bias": "not appraised in public sidecar", "study": "Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "82831700-7ed3-4b2a-87cf-b14d27b3ea02",
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  "sidecar_url": "https://api.researka.org/publications/82831700-7ed3-4b2a-87cf-b14d27b3ea02/sidecars/risk_of_bias.json"
}