Derivation Web

source_60ee01f3a9054d62

by researka:v2 · 2026-06-24 04:42:41.816351+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NAD+ Enhanced on Hearing Recovery in Sudden Sensorineural Hearing Loss: Randomized Controlled Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Development of a 31 P magnetic resonance spectroscopy technique to quantify NADH and NAD + at 3 T,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A randomized, controlled clinical trial demonstrates improved owner-assessed cognitive function in senior dogs receiving a senolytic and NAD+ precursor combination",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide riboside with pterostilbene (NRPT) increases NAD + in patients with acute kidney injury (AKI): a randomized, double-blind, placebo-controlled, stepwise safety study of escalating doses of NRPT in patients with AKI",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"A Combination of Nicotinamide and D-Ribose (RiaGev) Is Safe and Effective to Increase NAD + Metabolome in Healthy Middle-Aged Adults: A Randomized, Triple-Blind, Placebo-Controlled, Cross-Over Pilot Clinical Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Refining Prognosis in Cirrhosis Patients With Ascites: Impact of Acute vs. Non‐Acute Decompensation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acupuncture as Add-on Therapy to SSRIs Can Improve Outcomes of Treatment for Anxious Depression: Subgroup Analysis of the AcuSDep Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of Nicotinamide Adenine Dinucleotide on Older Patients with Heart Failure,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Relationship between sperm NAD + concentration and reproductive aging in normozoospermia men:A Cohort study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The complexity of nicotinamide adenine dinucleotide (NAD), hypoxic, and aryl hydrocarbon receptor cell signaling in chronic kidney disease",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effects of NAD+ precursor (nicotinic acid and nicotinamide) supplementation on weight loss and related hormones: a systematic review and meta-regression analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A Liposomal Formulation Enhances the Anti-Senescence Properties of Nicotinamide Adenine-Dinucleotide (NAD + ) in Endothelial Cells and Keratinocytes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Ameliorating effect of 6-week swimming exercise on mice with experimental autoimmune encephalomyelitis (EAE) by reducing fetuin-A and increasing AMPK & NAD ⁺ levels in liver tissue,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
SERPINE1 drives ferroptosis in acute respiratory distress syndrome by disrupting mitochondrial NAD + homeostasis and suppressing Sirt3 activity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The impacts of continuous improvements in air quality on mortality in Beijing: A longitudinal comparative study.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Oral nicotinamide riboside raises NAD+ and lowers biomarkers of neurodegenerative pathology in plasma extracellular vesicles enriched for neuronal origin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Studenski 2011,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cesari 2009,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "941512c2-b114-4c13-986c-205ddb9531a5",
  "researka_submission_id": "bb62000f-4298-4984-b576-428e0dd7d25e",
  "sidecar_name": "evidence_table.csv",
  "sidecar_url": "https://api.researka.org/publications/941512c2-b114-4c13-986c-205ddb9531a5/sidecars/evidence_table.csv"
}