Derivation Web

source_62632344e1b84ff7

by researka:v2 · 2026-06-22 01:25:38.932428+04:00

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A Brief Narrative Review.", "url": "https://pubmed.ncbi.nlm.nih.gov/40465202/"}, {"doi": "10.3390/ph18010055", "study": "The Gut Microbiota-Related Antihyperglycemic Effect of Metformin", "url": "https://pubmed.ncbi.nlm.nih.gov/39861118/"}, {"doi": "10.21203/rs.3.rs-5920485/v1", "study": "Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.", "url": "https://pubmed.ncbi.nlm.nih.gov/39989956/"}, {"doi": "10.1016/j.heliyon.2024.e37883", "study": "Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies.", "url": "https://pubmed.ncbi.nlm.nih.gov/39381110/"}, {"doi": "10.1111/acel.13802", "study": "Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics", "url": "https://pubmed.ncbi.nlm.nih.gov/36864750/"}], "claim": "This evidence map surveys 19 independent metformin treatment sources drawn from the Tier-2 corpus and classified as direct findings. They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1007/s12325-025-03256-x", "study": "Metformin: Old Drug, New Therapeutic Potential in the Skin? A Brief Narrative Review.", "url": "https://pubmed.ncbi.nlm.nih.gov/40465202/"}, {"doi": "10.3390/ph18010055", "study": "The Gut Microbiota-Related Antihyperglycemic Effect of Metformin", "url": "https://pubmed.ncbi.nlm.nih.gov/39861118/"}, {"doi": "10.21203/rs.3.rs-5920485/v1", "study": "Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.", "url": "https://pubmed.ncbi.nlm.nih.gov/39989956/"}, {"doi": "10.1016/j.heliyon.2024.e37883", "study": "Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies.", "url": "https://pubmed.ncbi.nlm.nih.gov/39381110/"}, {"doi": "10.1111/acel.13802", "study": "Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics", "url": "https://pubmed.ncbi.nlm.nih.gov/36864750/"}], "claim": "| Caenorhabditis elegans | control | Metformin causes an 86% increase in S-adenosylmethionine (SAMe) | 2025 doi:10.3390/ph18010055 |", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1007/s12325-025-03256-x", "study": "Metformin: Old Drug, New Therapeutic Potential in the Skin? 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A Brief Narrative Review.", "url": "https://pubmed.ncbi.nlm.nih.gov/40465202/"}, {"doi": "10.3390/ph18010055", "study": "The Gut Microbiota-Related Antihyperglycemic Effect of Metformin", "url": "https://pubmed.ncbi.nlm.nih.gov/39861118/"}, {"doi": "10.21203/rs.3.rs-5920485/v1", "study": "Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.", "url": "https://pubmed.ncbi.nlm.nih.gov/39989956/"}, {"doi": "10.1016/j.heliyon.2024.e37883", "study": "Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies.", "url": "https://pubmed.ncbi.nlm.nih.gov/39381110/"}, {"doi": "10.1111/acel.13802", "study": "Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics", "url": "https://pubmed.ncbi.nlm.nih.gov/36864750/"}], "claim": "| mice on high-fat diet | without metformin | Clostridium cocleatum (0.10%±0.09%) abundances increased significantly after metformin tre… | 2014 doi:10.1128/aem.01357-14 |", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1007/s12325-025-03256-x", "study": "Metformin: Old Drug, New Therapeutic Potential in the Skin? 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