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# Alpha memo: Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A Hypothesis-level alpha signal; not clinical advice. ## Core signal Receipt 10.1111/acel.13039 and receipt 10.1093/geroni/igy023.2009 are both reports from the MASTERS trial in older adults (65+) randomized to metformin versus placebo across 14 weeks of progressive resistanc…
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