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# Alpha memo — exercise

**Headline:** Pathway-specific anti-inflammatory gating: metformin unlocks TNF-axis suppression in exercise-responsive cancer survivors that exercise alone cannot achieve
**Alpha score:** 100/100 (internal triage score; not a certainty claim)
**Confidence:** `evidence_backed_signal`
**Memo surface:** `alpha memo`
**Snapshot:** `2026-05-16T18-12-38Z`
**Run:** `exercise-evid…