Derivation Web

source_69462a684f574763

by researka:v2 · 2026-06-24 16:35:52.001096+04:00

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Grouped by direction, directionally favorable: 2 receipt(s) | other/mixed: 3 receipt(s). The source facts cover 5 population context(s) and 5 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. Concrete source-level examples: whey protein supplementation significantly improved appendicular lean mass and physical function (SMD = 1.211; 95% CI: 0.588, 1.834; n = 16); significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given; at first restaging, 32.0 ng/mL vs 18.7 ng/mL (difference, 12.8 ng/mL [95% CI, 9.0 to 16.6], P < .001).", "type": "claim"}, {"id": "claim_4", "text": "other/mixed: The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study — significant decrease in advanced oxidation protein products levels over the 3-month period when higher vitamin D doses are given", "type": "claim"}, {"id": "claim_5", "text": "Specific moderators in this bundle are population/indication (Patients with type 2 diabetes on standard metformin therapy; Type 2 diabetes patients; Vitamin D deficient elderly persons (serum 25-(OH)D <30 ng/mL); patients with advanced or metastatic colorectal cancer; sarcopenic/frail older adults), study design/evidence type (primary/review). Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "type": "claim"}, {"id": "claim_6", "text": "The selected receipts group because each carries a fact-level extraction for vitamin D supplementation; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_7", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1016/j.advnut.2023.05.011", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Whey Protein Supplementation with or without Vitamin D on Sarcopenia-Related Measures: A Systematic Review and Meta-Analysis", "type": "source", "url": "https://doi.org/10.1016/j.advnut.2023.05.011", "year": 2023}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fendo.2021.610893", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Effects of Vitamin D Supplementation on Metabolic and Oxidative Stress Markers in Patients With Type 2 Diabetes: A 6-Month Follow Up Randomized Controlled Study", "type": "source", "url": "https://doi.org/10.3389/fendo.2021.610893", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1001/jama.2019.2402", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of High-Dose vs Standard-Dose Vitamin D<sub>3</sub> Supplementation on Progression-Free Survival Among Patients With Advanced or Metastatic Colorectal Cancer", "type": "source", "url": "https://doi.org/10.1001/jama.2019.2402", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fimmu.2019.00065", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial", "type": "source", "url": "https://doi.org/10.3389/fimmu.2019.00065", "year": 2019}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3390/nu10030375", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Effect of Vitamin D Supplementation on Glycemic Control in Type 2 Diabetes Patients: A Systematic Review and Meta-Analysis", "type": "source", "url": "https://doi.org/10.3390/nu10030375", "year": 2018}], "publication_id": "55da1db9-6ae1-4b52-ab80-ab62f546525d", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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