Derivation Web

source_69e353b7d4af4dbd

by researka:v2 · 2026-06-29 12:55:24.347344+04:00

{"publication_id": "06888b97-d174-4ea3-8963-a9e4112d22e8", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1186/s12970-016-0143-x", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "The NAD + precursor nicotinamide riboside decreases exercise performance in rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12970-016-0143-x"}, {"directness": "primary", "doi": "10.1007/s00394-019-01919-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00394-019-01919-4"}], "claim": "Receipt 1:** \"The NAD+ precursor nicotinamide riboside decreases exercise performance in rats\" (2016) — Chronic 21-day NR administration at 300 mg/kg/day in young Wistar rats showed a tendency toward worse swimming performance versus saline controls.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1186/s12970-016-0143-x", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "The NAD + precursor nicotinamide riboside decreases exercise performance in rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12970-016-0143-x"}, {"directness": "primary", "doi": "10.1007/s00394-019-01919-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00394-019-01919-4"}], "claim": "Receipt 2:** \"Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study\" (2020) — Acute NR supplementation in older men (who exhibited lower erythrocyte NAD(P)H and higher urine F₂-isoprostanes at baseline) increased NAD(P)H levels, decreased oxidative stress, and improved VO₂-related performance, while no comparable benefit appeared in young subjects.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1186/s12970-016-0143-x", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "The NAD + precursor nicotinamide riboside decreases exercise performance in rats", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1186/s12970-016-0143-x"}, {"directness": "primary", "doi": "10.1007/s00394-019-01919-4", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s00394-019-01919-4"}], "claim": "Why this is surprising:** Receipt 1 made plausible the expectation that chronic NR would uniformly impair exercise output, yet Receipt 2 shows the same anchor can flip toward ergogenic benefit when baseline redox status is deficient, suggesting age-dependent reversal rather than a stable directional effect.", "claim_id": "claim_3"}]}

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