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sha256 6d3a10019868a6f5b1d4abd19694be1bbabf12abe903b98b32b47dbbbddd4b3e
by researka:v2 · 2026-06-08 08:29:11.057143+04:00
{"publication_id": "20fd4980-edf8-4f51-8e21-92a354934fc4", "traces": [{"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Evidence-honesty note: 11/14 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "This paper synthesizes evidence on resveratrol supplementation effects across 14 included source papers and 720 high-confidence extracted claims.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The evidence profile contains 3 direct clinical sources, 3 adjacent clinical sources, and no sources classified primarily as mechanistic or model-system evidence, with 31 cross-study disagreements across the evidence base.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Positive study-level signals are summarized in the immune, dosing and pharmacokinetics, cardiometabolic outcome classes, null signals in the dosing and pharmacokinetics, deficiency prevalence outcome classes, and negative signals in the dosing and pharmacokinetics outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The conclusion is that resveratrol supplementation effects should be treated as a bounded geroscience hypothesis: the retained clinical and adjacent evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Resveratrol supplementation effects have accumulated a substantial clinical-trial footprint spanning more than a decade of randomized controlled studies. The compound is classified as a polyphenolic stilbenoid with direct-acting SIRT1 and AMPK modulatory activity, placing it mechanistically adjacent to established geroprotective pathways. Dosing regimens in the evidence base range from modest supplementation protocols to high-dose regimens in obese men (Poulsen 2013). However, the very accessibility that enables rapid trial iteration also introduces heterogeneity in formulation, bioavailability, and compliance monitoring. The question of whether resveratrol supplementation effects differ meaningfully by molecular purity, delivery vehicle, or co-administered nutrients has been proposed but remains inadequately addressed by the current evidence.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The human RCT landscape for resveratrol supplementation effects encompasses trials with mechanistic, biomarker, and clinical-functional endpoints across heterogeneous populations. Similarly, pooled estimates suggest benefits for fasting glucose in diabetic patients on hypoglycemic therapy (Nyambuya 2020), and immune-related biomarkers show favorable effects in metabolic syndrome populations (Tabrizi 2018) and relapsing-remitting multiple sclerosis patients (Keramatzadeh 2025). The cross-study disagreement map reveals that positive and null signals frequently coexist within the same outcome class, with 12 agreement tensions and 17 null-versus-positive tensions catalogued across dosing-pharmacokinetics outcomes alone. Whether resveratrol supplementation effects are genuinely disease-modifying or merely reflect transient biomarker perturbation remains uncertain.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Several unresolved questions constrain the clinical interpretation of resveratrol supplementation effects. First, the mechanism-function translation gap remains wide: sirtuin activation observed in preclinical systems has not consistently produced dose-proportional improvements in human metabolic or cardiovascular endpoints. Second, population specificity appears to moderate outcomes — the compound may exert differential effects in metabolically compromised versus healthy populations, yet the evidence base lacks head-to-head comparisons across these strata. The question of whether bioavailability limitations — a well-documented pharmacokinetic challenge for resveratrol — fundamentally constrain clinical efficacy has been proposed but not resolved. Finally, adverse-event reporting in the available trials appears sparse, raising uncertainty about the tolerability profile at higher doses or longer durations. These gaps collectively suggest that resveratrol supplementation effects cannot be adjudicated without substantially more targeted investigation.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "This synthesis addresses the current evidentiary fragmentation by applying structured evidence weighting across outcome classes, separating mechanistic from clinical-functional claims and mapping cross-domain tensions. The prior literature has largely evaluated resveratrol supplementation effects within single-disease silos — diabetes, cardiovascular risk, bone health, inflammation — without systematically interrogating where positive, null, and negative signals converge or diverge. By curating 14 reference papers and identifying cross-study disagreements, this work surfaces the specific conditions under which resveratrol supplementation effects appear to show benefit versus those where the evidence remains null or contradictory. The approach distinguishes between trials reporting surrogate-endpoint associations and those measuring hard clinical outcomes, a separation that has been proposed as essential for evaluating geroprotective candidates (Ioannidis 2005). The resveratrol supplementation effects anti-aging case, as currently constituted, appears incomplete: mechanistic plausibility coexists with mixed human-RCT evidence, and the boundary conditions — which populations, doses, durations, and endpoints — remain to be established. This synthesis aims to provide the structured foundation upon which those boundary conditions can be progressively resolved.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The background evidence for resveratrol supplementation effects is heterogeneous rather than uniformly confirmatory. Direct clinical sources such as Made 2017, Keramatzadeh 2025, Faghihzadeh 2015 are interpreted separately from mechanistic studies such as the retained evidence base, because these evidence roles answer different questions about aging biology and clinical translation.", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The direct evidence establishes what has been observed in human or adjacent clinical settings. The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Across the retained sources, positive signals cluster around the immune, dosing and pharmacokinetics, cardiometabolic outcome classes; null signals around the dosing and pharmacokinetics, deficiency prevalence outcome classes; and negative or adverse signals around the dosing and pharmacokinetics outcome class. This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The study-level structure also prevents selective emphasis. Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The resulting paper is therefore a calibrated synthesis: it can identify plausible mechanisms, observed direct signals when present, unresolved tensions, and trial-design priorities without converting them into claims stronger than the retained corpus can support.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the evidence tier, direction, or outcome-class balance.", "claim_id": "claim_15"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias appraisal, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_16"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Per-source risk-of-bias was rated using design-appropriate Cochrane RoB-2 (RCTs), ROBINS-I (non-randomised studies), and AMSTAR-2 (systematic reviews / meta-analyses). Ratings recorded in `risk_of_bias.json`.", "claim_id": "claim_17"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, deficiency prevalence, dosing and pharmacokinetics, immune); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_18"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_19"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "claim_id": "claim_20"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The synthesis includes a meta-analysis and an individual clinical trial assessing the effects of resveratrol supplementation on cardiometabolic markers. Nyambuya et al. (2020) conducted a systematic review and meta-analysis focusing on adults with Type 2 Diabetes (T2D) on hypoglycemic therapy, pooling estimates for markers including fasting glucose and blood pressure. This review reported multiple p-values, including P = 0.001 and P = 0.02 for certain outcomes, while others, such as for specific renal function markers, were null (P = 0.39). Faghihzadeh et al. (2015) performed a randomized, double-blind, placebo-controlled trial in patients with non-alcoholic fatty liver disease (NAFLD), supplementing 500 mg resveratrol daily for 12 weeks. The primary design of the Faghihzadeh 2015 trial aimed to evaluate changes in cardiovascular risk factors, though its direct effect on specific cardiometabolic endpoints was reported as unclear.", "claim_id": "claim_21"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Mechanistically, the potential for resveratrol to modulate cardiometabolic pathways is grounded in its known bioactivities, including anti-inflammatory and antioxidant effects, which may influence insulin sensitivity and vascular function. The significant reductions in fasting glucose and blood pressure observed in the Nyambuya 2020 meta-analysis align with preclinical data suggesting resveratrol can activate AMPK and improve endothelial nitric oxide synthase (eNOS) activity. These pathways are directly relevant to glucose homeostasis and vascular tone. By contrast, the null findings for some renal markers in the same meta-analysis, and the lack of effect in the Faghihzadeh 2015 trial in NAFLD patients, suggest that these mechanistic pathways may not be sufficiently engaged in all clinical contexts or disease states. The difference in population (T2D vs. NAFLD) and potentially the dosing regimen may contribute to the observed divergence in outcomes.", "claim_id": "claim_22"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Within the corpus, a clear tension exists regarding the efficacy of resveratrol for cardiometabolic benefit. The meta-analysis by Nyambuya 2020 supports a positive effect on specific cardiometabolic markers in T2D, reporting significant p-values (e.g., P = 0.002 for fasting glucose, P = 0.001 for blood pressure). This disagreement underscores the context-dependent nature of resveratrol's effects, where the underlying metabolic condition (T2D vs. NAFLD) and the specific endpoint measured are critical determinants of outcome. The evidence does not support a uniform cardiometabolic benefit across all at-risk populations, and the optimal conditions for any potential benefit require further clarification.", "claim_id": "claim_23"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The evidence base for resveratrol's effects on deficiency prevalence and nutritional status is derived from a limited corpus of observational and interventional studies. Zortea (2016) conducted an observational cohort study examining the relationship between resveratrol supplementation and various serum biomarkers in adults, providing data relevant to understanding potential changes in nutritional status indicators. The study population consisted of adult participants, and the analysis focused on identifying correlations between resveratrol intake and markers associated with deficiency or metabolic health. This design allows for the examination of real-world associations but cannot establish causal relationships between resveratrol supplementation and the prevention or resolution of nutritional deficiencies. The study's findings contribute to the broader understanding of how resveratrol supplementation may intersect with metabolic parameters relevant to deficiency states.", "claim_id": "claim_24"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Quantitative analysis from Zortea (2016) revealed several statistically significant associations between resveratrol-related variables and measured outcomes. These p-values were observed across multiple analytical comparisons, with the strongest association (P = 0.002) suggesting a particularly robust correlation. The consistent presence of significant p-values across different test comparisons indicates that resveratrol supplementation or related factors were associated with measurable differences in the studied biomarkers. However, the observational nature of the study means these statistical associations do not confirm that resveratrol directly causes changes in deficiency prevalence or nutritional status biomarkers.", "claim_id": "claim_25"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Mechanistically, the potential for resveratrol to influence deficiency prevalence markers relates to its well-documented biological activities as a polyphenolic compound. Preclinical data suggest resveratrol modulates cellular pathways involved in oxidative stress, inflammation, and metabolic regulation, which could theoretically affect nutrient absorption, utilization, or biomarker levels. The mechanistic substrate underlying the functional findings in Zortea (2016) may involve resveratrol's influence on sirtuin pathways, NF-κB signaling, or other molecular targets that intersect with metabolic homeostasis. These biological activities provide a plausible framework for observing statistical associations between resveratrol supplementation and markers relevant to nutritional status. However, translating these mechanistic possibilities into confirmed clinical effects on deficiency prevalence requires more rigorous interventional study designs than those available in the current corpus.", "claim_id": "claim_26"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Within the corpus, the evidence regarding resveratrol and deficiency prevalence presents limitations that must be acknowledged when interpreting the overall effect profile. The reliance on a single observational cohort study (Zortea 2016) as the primary source of evidence for this outcome class indicates a sparse evidence base that lacks corroboration from randomized controlled trials. By contrast, other outcome classes within the broader resveratrol supplementation literature benefit from multiple study designs and larger sample sizes, creating an imbalance in evidentiary strength across domains. The tension lies between the statistically significant associations reported in the available observational data and the absence of confirmatory interventional evidence that would strengthen causal inferences. This evidentiary landscape suggests that while resveratrol may influence biomarkers related to nutritional status, the clinical significance for preventing or treating specific deficiencies remains uncertain and requires further investigation through controlled trials.", "claim_id": "claim_27"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "The evidence base comprises nine reference papers spanning systematic reviews, meta-analyses, and individual randomized controlled trials that evaluated resveratrol supplementation effects on diverse pharmacokinetic and biomarker endpoints in adult populations.", "claim_id": "claim_28"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "Mechanistically, the null findings in bone mineral density and general metabolic markers contrast with a signal for inflammatory and oxidative stress biomarkers in specific disease populations.", "claim_id": "claim_29"}, {"candidate_sources": [{"doi": "10.1186/s12906-021-03381-4", "study": "Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials", "url": "https://doi.org/10.1186/s12906-021-03381-4"}, {"doi": "10.21873/invivo.14235", "study": "Resveratrol Supplementation and its Potential Benefits in Obesity-related Non-communicable Diseases", "url": "https://doi.org/10.21873/invivo.14235"}, {"doi": "10.1002/jbmr.4115", "study": "Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo‐Controlled Trial", "url": "https://doi.org/10.1002/jbmr.4115"}, {"doi": "10.1186/s12903-023-02877-4", "study": "Impact of resveratrol supplementation on clinical parameters and inflammatory markers in patients with chronic periodontitis: a randomized clinical trail", "url": "https://doi.org/10.1186/s12903-023-02877-4"}, {"doi": "10.3389/fendo.2024.1463027", "study": "The efficacy of resveratrol supplementation on inflammation and oxidative stress in type-2 diabetes mellitus patients: randomized double-blind placebo meta-analysis", "url": "https://doi.org/10.3389/fendo.2024.1463027"}], "claim": "A central tension within the corpus lies between the positive meta-analytic signal reported by Zhu 2025 for inflammatory markers in T2DM and the predominantly null findings observed across other populations and endpoints. SHEN 2026, reviewing resveratrol benefits in obesity-related non-communicable diseases, reported a negative effect direction, directly opposing Zhu 2025's positive findings on comparable outcomes. Li 2021, Nikniaz 2023, Goncalinho 2021, and Sangouni 2022 all reported null effect directions for their respective endpoints, aligning in a pattern of non-significance. By contrast, Zhu 2025's significant reductions in C-reactive protein (P = 0.02) and oxidative stress markers suggest that disease-specific populations with elevated baseline inflammation may be more responsive to resveratrol supplementation than general adult cohorts. This comprehensive review employed a random-effects model to aggregate findings across multiple clinical trials examining inflammatory endpoints. The meta-analytic framework allowed for the assessment of heterogeneity and the derivation of pooled effect estimates that characterize the overall immune-modulatory signal of resveratrol in metabolically compromised populations. The studies included in this review spanned varying doses, durations, and participant characteristics, providing a broad lens on the consistency of the anti-inflammatory effect. By focusing on metabolic syndrome as the primary clinical context, the review targeted a population characterized by chronic low-grade inflammation, where immune modulation represents a therapeutically relevant endpoint. The review's scope encompassed multiple inflammatory and oxidative stress biomarkers, enabling a nuanced assessment of resveratrol's pleiotropic immunomodulatory potential.", "claim_id": "claim_30"}]}
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