Derivation Web

source_6e46d22236594b48

by researka:v2 · 2026-06-15 01:09:06.917867+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Metformin Treatment With or Without Mediterranean Diet for the Prevention of Age-Related Diseases in People With Metabolic Syndrome: The MeMeMe Randomized Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin has heterogeneous effects on model organism lifespans and is beneficial when started at an early age in Caenorhabditis elegans : A systematic review and meta‐analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Letrozole, abemaciclib and metformin in endometrial cancer: a non-randomized phase 2 trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Association of metformin, aspirin, and cancer incidence with mortality risk in adults with diabetes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Do We Have Enough Evidence That Metformin Is Superior to Other Antidiabetic Drugs in Pancreatic Cancer Risk Reduction?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Olaparib combined to metronomic cyclophosphamide and metformin in women with recurrent advanced/metastatic endometrial cancer: the ENDOLA phase I/II trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Metformin: A Dual-Role Player in Cancer Treatment and Prevention: A Comprehensive Systematic Review and Meta-Analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Metformin and weight loss medication impact on survival outcomes in older women with obesity-related cancers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Clenbuterol and metformin ameliorate cachexia parameters, but only clenbuterol reduces tumor growth via lipid peroxidation in Walker 256 tumor-bearing rats",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association of metformin use with risk and survival outcome of esophageal cancer in patients with diabetes: A systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Efficacy of metformin as an adjuvant therapy in gynecologic malignancies: a meta-analysis of randomized controlled trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Time-Restricted Eating and Metformin in Invasive Breast Cancer or DCIS: A Randomized, Phase IIb, Presurgical Trial. Preliminary Safety Analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Statin use and breast cancer-specific mortality and recurrence: a systematic review and meta-analysis including the role of immortal time bias and tumour characteristics,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Extracellular Matrix–MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: a phase II, randomized study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effectiveness of drug-loaded poly(ethylene glycol) and poly(lactic-co-glycolic-acid) nanoparticles in the in vitro treatment of breast cancer: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Smartphone-Based Physical Activity Program to Reduce “Chemo-Brain” Symptoms and Improve Health in Cancer Survivors With and Without Type 2 Diabetes: Protocol for a Single-Arm Pre-Post Pilot Trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bibliometric analysis of metformin as an immunomodulator (2013–2024),not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Association between preoperative metformin exposure and postoperative nausea and vomiting in patients undergoing general anaesthesia: a protocol for a prospective observational cohort study in a Chinese tertiary hospital,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Tinetti 1988.** _Tinetti ME, Speechley M, Ginter SF. Risk factors for falls among elderly persons living in the community. N Engl J Med. 1988;319(26):1701-1707._ DOI: 10.1056/NEJM198812293192604. PMID: 3205267.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
**ADA 2024.** _American Diabetes Association. Standards of Care in Diabetes. Diabetes Care. 2024;47(Suppl 1)._ DOI: 10.2337/dc24-S006.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Owen 2000.** _Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J. 2000;348 Pt 3:607-614._ PMID: 10839993.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Anisimov 2008.** _Anisimov VN, Berstein LM, Egormin PA, et al. Metformin slows down aging and extends life span of female SHR mice. Cell Cycle. 2008;7(17):2769-2773._ PMID: 18728386.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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