Derivation Web

source_6e64525fb990461c

by researka:v2 · 2026-06-21 15:38:17.770738+04:00

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"10.1186/s43556-025-00402-3", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine attenuates whole-abdominal irradiation-induced multi-organ injury via the gut-heart-brain axis by modulating calcium voltage-gated channel subunit alpha1 C (Cacna1c) expression"}, {"directness": "primary", "doi": "10.2147/JMDH.S547548", "risk_of_bias": "not appraised in public sidecar", "study": "The Current Situation and Future Trends of Ergothioneine in Biology and Medical Research: A Bibliometric Analysis"}, {"directness": "primary", "doi": "10.3390/microorganisms14051088", "risk_of_bias": "not appraised in public sidecar", "study": "Engineering Escherichia coli for Ergothioneine Production via Metabolic Engineering and Fermentation Optimization"}, {"directness": "primary", "doi": "10.1002/1873-3468.70136", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy"}, {"directness": "primary", "doi": "10.1186/s12934-020-01421-1", "risk_of_bias": "not appraised in public sidecar", "study": "Successful biosynthesis of natural antioxidant ergothioneine in Saccharomyces cerevisiae required only two genes from Grifola frondosa"}, {"directness": "primary", "doi": "10.1016/j.redox.2026.104090", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine rescues obesity-induced testicular dysfunction via dual restoration of steroidogenesis and mitochondrial redox homeostasis"}, {"directness": "primary", "doi": "10.1007/s00253-025-13505-2", "risk_of_bias": "not appraised in public sidecar", "study": "Enhanced production of ergothioneine in Aspergillus oryzae"}, {"directness": "primary", "doi": "10.1038/s41598-026-48438-x", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine as a potential protective agent against macular degeneration and other eye disorders"}, {"directness": "primary", "doi": "10.1111/pcn.13893", "risk_of_bias": "not appraised in public sidecar", "study": "Serum ergothioneine and risk of dementia in a general older Japanese population: the Hisayama Study"}, {"directness": "primary", "doi": "10.3390/ijms262110263", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine Attenuates Oxaliplatin-Induced Peripheral Neuropathy Without Compromising Antitumor Efficacy"}, {"directness": "primary", "doi": "10.3390/nu17030517", "risk_of_bias": "not appraised in public sidecar", "study": "The Association Between Serum Ergothioneine Concentration and Japanese Dietary Habits: The Third Survey of the ROAD Study"}, {"directness": "primary", "doi": "10.3390/nu14061177", "risk_of_bias": "not appraised in public sidecar", "study": "Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging"}, {"directness": "primary", "doi": "10.3390/biology12020196", "risk_of_bias": "not appraised in public sidecar", "study": "Cognitive Healthy Aging in Mice: Boosting Memory by an Ergothioneine-Rich Hericium erinaceus Primordium Extract"}, {"directness": "primary", "doi": "10.3390/ijms27052179", "risk_of_bias": "not appraised in public sidecar", "study": "Uncovering the Potential Mechanisms of Ergothioneine in Neuroinflammation Through Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro Validation"}, {"directness": "primary", "doi": "10.1080/07853890.2025.2555742", "risk_of_bias": "not appraised in public sidecar", "study": "Advances and prospects of ergothioneine in the treatment of cognitive frailty"}, {"directness": "primary", "doi": "10.3390/membranes15110328", "risk_of_bias": "not appraised in public sidecar", "study": "Ergothioneine Thione Spontaneously Binds to and Detaches from the Membrane Interphase"}, {"directness": "primary", "doi": "10.3390/antiox15040519", "risk_of_bias": "not appraised in public sidecar", "study": 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a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1111/j.1532-5415.2006.00701.x", "risk_of_bias": "not appraised in public sidecar", "study": "Perera 2006"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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