Derivation Web

source_746a8f52081445b5

by researka:v2 · 2026-06-29 06:38:03.422875+04:00

{"publication_id": "2371a466-c045-460d-a766-e242574bcc65", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1016/j.exger.2024.112479", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1016/j.exger.2024.112479"}, {"directness": "primary", "doi": "10.1002/ptr.8171", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1002/ptr.8171"}], "claim": "Two 2024 randomized trials in older adults define the same dose/regime but land on different ledger sides. 10.1002/ptr.8171 is a systematic review of randomized clinical trials in older adults reporting that resveratrol combined with exercise improved exercise adaptation, muscle function, and physical performance/mobility. 10.1016/j.exger.2024.112479 is the embedded dose-ranging trial that explicitly set out to test resveratrol + exercise training on trimethylamine-N-oxide in older adults with high CVD risk and observed that TMAO concentration increased over time regardless of treatment arm (p = 0.04), with each dose producing distinct metabolite signatures.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1016/j.exger.2024.112479", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1016/j.exger.2024.112479"}], "claim": "10.1016/j.exger.2024.112479 — role=evidence; design=randomized_trial; population=human older adults with high CVD risk; outcome=dose/risk (TMAO and metabolite signatures); direction=negative/positive; support=direct/high.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1002/ptr.8171", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1002/ptr.8171"}], "claim": "10.1002/ptr.8171 — role=positive_signal; design=randomized_trial systematic review; population=human older adults; outcome=chronic/dose/long (muscle function, mobility, neuroprotection, cognition); direction=positive; support=direct/high.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1249/MSS.0000000000000620", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1249/MSS.0000000000000620"}], "claim": "10.1249/MSS.0000000000000620 — role=mechanism; design=randomized_trial review; population=human; outcome=performance/risk/stress (ROS as adaptive signal); direction=negative/positive; support=direct/high.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1113/jphysiol.2013.266999", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Attenuated effects of exercise with an antioxidant supplement: too much of a good thing?", "support_kind": "direct_doi_match", "url": "https://doi.org/10.1113/jphysiol.2013.266999"}], "claim": "10.1113/jphysiol.2013.266999 — role=boundary; design=randomized_trial commentary; population=human; outcome=damage/long/risk (vascular function); direction=negative; support=direct/high.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1016/j.exger.2024.112479", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of resveratrol on changes in trimethylamine-N-oxide and circulating cardiovascular factors following exercise training among older adults.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1016/j.exger.2024.112479"}, {"directness": "primary", "doi": "10.1002/ptr.8171", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Effects and safety of resveratrol supplementation in older adults: A comprehensive systematic review.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1002/ptr.8171"}, {"directness": "primary", "doi": "10.1249/MSS.0000000000000620", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Dietary Antioxidants as Modifiers of Physiologic Adaptations to Exercise.", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1249/MSS.0000000000000620"}, {"directness": "primary", "doi": "10.1113/jphysiol.2013.266999", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Attenuated effects of exercise with an antioxidant supplement: too much of a good thing?", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1113/jphysiol.2013.266999"}], "claim": "Receipts describe trial and review-level safety reporting only; no clinical advice is inferred. The TMAO increase and the attenuated-exercise boundary are observed findings in the cited studies, not generalizable safety claims.", "claim_id": "claim_6"}]}

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