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# Alpha memo: Maternal metformin may not travel as a single direction of effect across the maternal–placental interface and the fetal islet **One-sentence alpha:** Receipt 1 makes plausible a maternal-side, adaptive benefit of metformin against hyperemesis gravidarum, while Receipt 2 updates that fetal-side exposure to near-maternal metformin doses during maternal overnutrition may worsen offsprin…
sha256 f420227550a6743d…