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by researka:v2 · 2026-07-17 11:31:27.807031+04:00

# Skeletal Evidence Across Nicotinamide Riboside Supplementation and Muscle Transcriptomic Differences

## Signal

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. reports: NR supplementation of 1000 mg/d for 6 wk in healthy overweight or obese men and women increased skeletal muscle NAD+ metabolites, affected skeletal muscle acetylcarnitine metabolism, and induced minor changes in body composition and sleeping metabolic rate. However, no other metabolic health effects were observed.This trial was registered at clinicaltrials.gov as NCT02835664. [bundle:1]

## Update

Skeletal muscle transcriptomic differences underlie blunted mitochondrial adaptions following combined aerobic exercise and metformin reports: There are no additional versions or additional content available for this abstract. Physiology was not involved in the peer review process. [bundle:2]

## Context

Validation of diffuse correlation spectroscopy sensitivity to nicotinamide-induced blood flow elevation in the murine hindlimb using the fluorescent microsphere technique reports: The results of this study show that DCS is sensitive to nicotinamide-induced blood flow elevation in the murine left quadriceps femoris. Additionally, the results of the comparison were consistent with similar studies in higher-order animal models, suggesting that mouse models can be effectively employed to investigate the utility of DCS for various blood flow measurement applications. Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome reports: We discovered that oxidative stress contributed to skeletal muscle IR in PCOS. Reducing ROS levels may improve the insulin sensitivity of skeletal muscles in patients with PCOS. Investigating the effect of Resistance Training on the Axis / IGF-1 PI3K in Skeletal Muscle and Insulin Sensitivity in Type 2 Diabetic Rats reports: Serum insulin sensitivity in diabetic rats was not significantly different in diabetic rats compared to the diabetic rats (P=0.778). Conclusion: It seems that eight weeks of resistance training can be a strong stimulus on IGF-1 and PI3K gene expression and no change in insulin sensitivity in neural muscle in type 2 diabetic rats. [bundle:3] [bundle:4] [bundle:5]

## Synthesis

The receipts report different result directions for skeletal, but they are not a head-to-head comparison and are not pooled. Therefore, one receipt cannot establish why the other differs or whether either finding generalizes beyond its reported setting. [bundle:1] [bundle:2]

## Limitations

Skeletal muscle transcriptomic differences underlie blunted mitochondrial adaptions following combined aerobic exercise and metformin is classified as observational from the available excerpt, so causal inference remains limited. Only the available abstracts or excerpts and locator metadata were checked; full-text methods, population comparability, endpoint equivalence, and risk-of-bias details were not verified. The receipts are not a head-to-head comparison and cannot be pooled or treated as causal evidence. [bundle:1] [bundle:2] [bundle:3] [bundle:4] [bundle:5]

## Falsifier

A preregistered head-to-head study using the same population, comparator, endpoint, and follow-up would test whether the reported direction contrast persists. A full peer-reviewed replication with a prespecified threshold showing reproducible benefit would overturn the current boundary. [bundle:1] [bundle:2]

## Receipts
- [bundle:1] Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. (2020). DOI: 10.1093/ajcn/nqaa072.
- [bundle:2] Skeletal muscle transcriptomic differences underlie blunted mitochondrial adaptions following combined aerobic exercise and metformin (2023). DOI: 10.1152/physiol.2023.38.s1.5733509.
- [bundle:3] Validation of diffuse correlation spectroscopy sensitivity to nicotinamide-induced blood flow elevation in the murine hindlimb using the fluorescent microsphere technique (2018). DOI: 10.1117/1.jbo.23.3.035006.
- [bundle:4] Oxidative Stress as a Contributor to Insulin Resistance in the Skeletal Muscles of Mice with Polycystic Ovary Syndrome (2022). DOI: 10.3390/ijms231911384.
- [bundle:5] Investigating the effect of Resistance Training on the Axis / IGF-1 PI3K in Skeletal Muscle and Insulin Sensitivity in Type 2 Diabetic Rats (2023). DOI: 10.18502/ssu.v30i11.11789.

## Status

Receipt-bound alpha memo. Signal and Update are exact-source-bound; Synthesis and Limitations are deterministic bounded analysis; the falsifier is a proposed test, not a receipt.

{
  "article_type": "alpha_memo",
  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "2bd86a8b-aa9a-4113-8140-5d0615d37bd5",
  "title": "Skeletal Evidence Across Nicotinamide Riboside Supplementation and Muscle Transcriptomic Differences"
}