source · application/json
source_75893b5f5ab942d1
sha256 3fe4876724d4fef80a11e8164fc1d6ee638d5f75e488dfb6eabbef63fad6ae32
by researka:v2 · 2026-07-02 00:09:59.578752+04:00
{"publication_id": "798fcdb7-5e51-43e8-978e-937dfca0ad1c", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Evidence-honesty note: 24/36 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "This synthesis tests the thesis that evidence for Calcium Supplementation Effects is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Calcium supplementation has long been proposed as a low-cost public-health lever for bone, cardiovascular, and pregnancy-related outcomes, yet contemporary evidence has been complicated by discrepant findings across indications, populations, and dosing regimens.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "We conducted an AI-assisted structured evidence synthesis across the curated source set, applying a transparent audit trail in which each study was tagged for design, directness, outcome class, and direction of effect before integration.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Across the corpus, the evidence base is context-dependent rather than uniformly favorable: pre-eclampsia prevention, certain insulin-related endpoints, and selected bone-fracture outcomes show benefit, while older-adult and pregnancy inflammation biomarkers, recurrent cardiovascular events, and several body-composition endpoints remain null or unfavorable, with mechanistic plausibility (Ioannidis 2005) coexisting alongside sparse or mixed human-RCT confirmation.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "We conclude that calcium supplementation should not be framed as a monolithic intervention: the most defensible indications remain high-risk pregnancy, while bone-fracture benefit in community-dwelling older adults and cardiovascular safety in at-risk populations remain insufficiently resolved and warrant further direct, outcome-stratified randomized evaluation.", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Evidence-abstraction note.** The 36 retained reference papers are not 36 independent primary clinical trials: 24 are review, indirect, mechanistic, or registered-protocol source-level summaries, and 12 are classified as direct interventional evidence. Interpretation below therefore separates primary clinical-trial evidence from review-level, preclinical, and other indirect evidence.", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-calcium_supplementation_effects-v06-DAILY-2026-07-01T12-45-35Z-R2`.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, dosing and pharmacokinetics, immune and inflammation, longevity, muscle function, skeletal, fracture, and bone); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_11"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_12"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "Additional corpus sources included animal/preclinical evidence; | Source | Outcome class | Direction | Directness | Tier | Finding |", "claim_id": "claim_13"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Chen 2022 | Cardiometabolic | null | review | B2 | 27 extracted claim(s); receipt-level direction is the coded finding |", "claim_id": "claim_14"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Cormick 2020 | Cardiometabolic | unclear | indirect | B2 | representative non-significant statistic P = .408; not treated as positive or negative directional support unless source direction is coded |", "claim_id": "claim_15"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Cormick 2023 | Cardiometabolic | null | review | B2 | 20 extracted claim(s); receipt-level direction is the coded finding |", "claim_id": "claim_16"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Cormick 2024 | Cardiometabolic | null | review | B1 | representative non-significant statistic P = 0.45; not treated as positive or negative directional support unless source direction is coded |", "claim_id": "claim_17"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Dwarkanath 2024 | Cardiometabolic | null | direct | A1 | 24 extracted claim(s); receipt-level direction is the coded finding |", "claim_id": "claim_18"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1136/bmjopen-2021-060189", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT: secondary analysis of a 12-month randomised controlled trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1136/bmjopen-2021-060189"}, {"directness": "review-level", "doi": "10.1111/nyas.14729", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Calcium supplementation during pregnancy and long‐term offspring outcome: a systematic literature review and meta‐analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/nyas.14729"}, {"directness": "primary", "doi": "10.1177/0379572120944671", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "The Effect of Calcium Supplementation on Body Weight Before and During Pregnancy in Women Enrolled in the WHO Calcium and Preeclampsia Trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1177/0379572120944671"}, {"directness": "review-level", "doi": "10.1007/s10654-020-00710-8", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "Calcium intake, calcium supplementation and cardiovascular disease and mortality in the British population: EPIC-norfolk prospective cohort study and meta-analysis", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1007/s10654-020-00710-8"}, {"directness": "review-level", "doi": "10.7554/eLife.79002", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "The effect of calcium supplementation in people under 35 years old: A systematic review and meta-analysis of randomized controlled trials", "support_kind": "candidate_source_row", "url": "https://doi.org/10.7554/eLife.79002"}], "claim": "| Fu 2022 | Cardiometabolic | null | review | B2 | representative non-significant statistic P = 0.65; 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