Derivation Web

source_770e44597c4e4548

by researka:v2 · 2026-06-29 13:42:33.861932+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Association of low-dose naltrexone and transcranial direct current stimulation in fibromyalgia: a randomized, double-blinded, parallel clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose naltrexone’s utility for non-cancer centralized pain conditions: a scoping review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Low-Dose Naltrexone: What is the Evidence? A Narrative Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A systematic literature review on the clinical efficacy of low dose naltrexone and its effect on putative pathophysiological mechanisms among patients diagnosed with fibromyalgia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Low-Dose Naltrexone (LDN) for Chronic Pain at a Single Institution: A Case Series,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-dose naltrexone as an adjunctive treatment for major depressive disorder: findings from a randomized, double-blind, placebo-controlled hybrid parallel-arm study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy and safety of low-dose naltrexone for the management of fibromyalgia: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effective Doses of Low-Dose Naltrexone for Chronic Pain – An Observational Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Efficacy of Low-Dose Naltrexone and Predictors of Treatment Success or Discontinuation in Fibromyalgia and Other Chronic Pain Conditions: A Fourteen-Year, Enterprise-Wide Retrospective Analysis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose naltrexone and NAD+ for the treatment of patients with persistent fatigue symptoms after COVID-19,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Pilot RCT comparing low-dose naltrexone, gabapentin and placebo to reduce pain among people with HIV with alcohol problems",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-Dose Naltrexone for Managing Pain and Autonomic Symptoms in Patients With Dysautonomia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
No change in the consumption of thyroid hormones after starting low dose naltrexone (LDN): a quasi-experimental before-after study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-dose naltrexone for the induction of remission in patients with mild to moderate Crohn’s disease: protocol for the randomised, double-blinded, placebo-controlled, multicentre LDN Crohn study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Potential Therapeutic Benefit of Low Dose Naltrexone in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Role of Transient Receptor Potential Melastatin 3 Ion Channels in Pathophysiology and Treatment,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-dose naltrexone for the treatment of fibromyalgia: protocol for a double-blind, randomized, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy and safety of low-dose naltrexone (LDN) in fibromyalgia: a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Study protocol for a randomised, double-blinded, placebo-controlled phase III trial examining the add-on efficacy, cost–utility and neurobiological effects of low-dose naltrexone (LDN) in patients with fibromyalgia (INNOVA study)",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-dose naltrexone for post-COVID fatigue syndrome: a study protocol for a double-blind, randomised trial in British Columbia",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-dose naltrexone for treatment of pain in patients with fibromyalgia: a randomized, double-blind, placebo-controlled, crossover study",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"A randomized, double-blind, placebo-controlled, hybrid parallel-arm study of low-dose naltrexone as an adjunctive anti-inflammatory treatment for major depressive disorder",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extemporaneous Preparation and Effectiveness of Low-Dose Naltrexone for the Treatment of Uremic Pruritus: A Literature Review and Case Report,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Safety and Efficacy of Low-Dose Naltrexone in Patients with Fibromyalgia: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Low-Dose Naltrexone for Severe Fibromyalgia Syndrome: A Report of a Case With Two-Year Follow-Up,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose naltrexone as a treatment for vulvodynia: A case series,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-dose naltrexone as a treatment for chronic fatigue syndrome,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
190. EFFECTS OF LOW-DOSE NALTREXONE ON SALIENCE NETWORK CONNECTIVITY IN MAJOR DEPRESSIVE DISORDER,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Improvement in Hailey–Hailey disease with a combination of low-dose naltrexone and oral magnesium chloride: A case report,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Unexpected Increase in Bone Mineral Density With Rapamycin and Low-Dose Naltrexone: A Case Report of a 52-Year-Old Woman With Osteopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Low-Dose Naltrexone in Chronic Pain Management: Mechanisms, Evidence, and Clinical Implications",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Therapeutic Uses and Efficacy of Low-Dose Naltrexone: A Scoping Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Low-Dose Naltrexone in Rheumatological Diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-Dose Naltrexone Use in Postural Orthostatic Tachycardia Syndrome: A Case Series,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Is low-dose naltrexone effective in chronic pain management?,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
The Effect of Low-Dose Naltrexone on Medication in Inflammatory Bowel Disease: A Quasi Experimental Before-and-After Prescription Database Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Reduced Pro-Inflammatory Cytokines after Eight Weeks of Low-Dose Naltrexone for Fibromyalgia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Low-Dose Naltrexone for Pruritus in Systemic Sclerosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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