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# Alpha memo: nicotinamide exercise performance
**One-sentence alpha:** Nicotinamide riboside supplementation appears to carry an age- and baseline-dependent exercise signal rather than a clean positive effect.
**Receipt 1:** Wang et al. (2016, "The NAD+ precursor nicotinamide riboside decreases exercise performance in rats") — In 18 Wistar rats given 300 mg/kg/day NR or saline via gavage for 21 d…