Derivation Web

source_7b97e6ddb086412b

by researka:v2 · 2026-06-05 22:14:09.343122+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "9dac2b04-d8de-4675-a8de-11480ceb67ae", "sources": [{"directness": "review-level", "doi": "10.1111/acel.14392", "risk_of_bias": "not appraised in public sidecar", "study": "The impact of cysteine on lifespan in three model organisms: A systematic review and meta‐analysis"}, {"directness": "primary", "doi": "10.3390/microorganisms14020314", "risk_of_bias": "not appraised in public sidecar", "study": "Multi-Model Longevity Assays Reveal Lifespan- and Healthspan-Promoting Effects of Bacillus subtilis WTC019"}, {"directness": "primary", "doi": "10.1111/acel.70225", "risk_of_bias": "not appraised in public sidecar", "study": "Six Drivers of Aging Identified Among Genes Differentially Expressed With Age"}, {"directness": "primary", "doi": "10.1111/acel.70131", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin, Not Metformin, Mirrors Dietary Restriction‐Driven Lifespan Extension in Vertebrates: A Meta‐Analysis"}, {"directness": "primary", "doi": "10.3389/fpubh.2026.1735033", "risk_of_bias": "not appraised in public sidecar", "study": "Budget impact analysis of deep brain stimulation devices with different longevity in Parkinson's disease: insights from real-world data"}, {"directness": "review-level", "doi": "10.3389/fpsyg.2026.1722743", "risk_of_bias": "not appraised in public sidecar", "study": "A systematic review and meta-analysis of the effects of errorless motor learning on movement outcomes: a lifespan and impairment perspective"}, {"directness": "primary", "doi": "10.1007/s11357-024-01307-9", "risk_of_bias": "not appraised in public sidecar", "study": "Sport and longevity: an observational study of international athletes"}, {"directness": "review-level", "doi": "10.1002/cnr2.70507", "risk_of_bias": "not appraised in public sidecar", "study": "The Effect of Interferon Type I Adjuvant Therapy on the Lifespan and Complications of Glioma Patients Undergoing Chemotherapy: A Systematic Review and Meta‐Analysis"}, {"directness": "review-level", "doi": "10.3390/ijerph22050690", "risk_of_bias": "not appraised in public sidecar", "study": "Green Environments for Sustainable Brains: Parameters Shaping Adaptive Neuroplasticity and Lifespan Neurosustainability—A Systematic Review and Future Directions"}, {"directness": "primary", "doi": "10.1136/bmjopen-2025-115862", "risk_of_bias": "not appraised in public sidecar", "study": "Prefilled versus infused regional citrate anticoagulation during continuous renal replacement therapy on circuit lifespan: protocol for a randomised controlled trial"}, {"directness": "review-level", "doi": "10.3389/fpsyg.2026.1745013", "risk_of_bias": "not appraised in public sidecar", "study": "The influence of attachment and relational quality on developmental outcomes across the lifespan: a systematic review and meta-analytic insights (2014–2024)"}, {"directness": "primary", "doi": "10.3390/biom16010073", "risk_of_bias": "not appraised in public sidecar", "study": "Novel tRNA Synthetase Inhibitors Increase Healthspan, Lifespan, and Autophagic Flux in C. elegans"}, {"directness": "primary", "doi": "10.1101/2025.11.03.686437", "risk_of_bias": "not appraised in public sidecar", "study": "Estrogen-Mediated Suppression of IL-11 as a Hormonal Mechanism Underlying Female Longevity Advantage"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1136/bmj.c332", "risk_of_bias": "not appraised in public sidecar", "study": "Schulz 2010"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "9dac2b04-d8de-4675-a8de-11480ceb67ae",
  "researka_submission_id": "6dbb019b-4832-4d74-abbe-115b8f5ce1b2",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/9dac2b04-d8de-4675-a8de-11480ceb67ae/sidecars/risk_of_bias.json"
}