source · application/json
source_823e55bd6aa34057
sha256 efe557b55307eae251fb0ffe535e4f123972a44fa5f89346ecffe4feb6c2247e
by researka:v2 · 2026-05-28 13:36:34.410036+04:00
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This synthesis tests the thesis that evidence for Akkermansia muciniphila is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation. This paper synthesizes akkermansia muciniphila as an aging-related intervention across 78 included source papers and 2155 high-confidence extracted claims. The evidence profile contains 1 direct clinical source, 47 adjacent clinical sources, and 19 mechanistic or model-system sources, with 1184 cross-study disagreements across the evidence base. Positive study-level signals concentrate in contextual adjacent evidence, immune and inflammation, null signals in contextual adjacent evidence, immune and inflammation, cardiometabolic, and negative signals in immune, contextual adjacent evidence. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect. The conclusion is that akkermansia muciniphila remains a bounded geroscience case: mechanistic plausibility and selected clinical signals justify further targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "type": "claim"}, {"id": "claim_2", "text": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-akkermansia_muciniphila-v06-DAILY-2026-05-28T09-30-06Z`.", "type": "claim"}, {"id": "claim_3", "text": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating.", "type": "claim"}, {"id": "claim_4", "text": "Per-source risk-of-bias was rated using design-appropriate Cochrane RoB-2 (RCTs), ROBINS-I (non-randomised studies), and AMSTAR-2 (systematic reviews / meta-analyses). Ratings recorded in `risk_of_bias.json`.", "type": "claim"}, {"id": "claim_5", "text": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, dosing and pharmacokinetics, immune, immune and inflammation, longevity, safety and comorbidity, skeletal, fracture, and bone); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "type": "claim"}, {"id": "claim_6", "text": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "type": "claim"}, {"id": "claim_7", "text": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence.", "type": "claim"}, {"id": "claim_8", "text": "| Contextual Adjacent Evidence | n=47; claims=1406 | null signal in 40/47 sources | 1 direct; 31 indirect; 8 mechanistic; 7 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_9", "text": "| Immune and Inflammation | n=13; claims=264 | null signal in 10/13 sources | 6 indirect; 7 mechanistic | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_10", "text": "| Cardiometabolic | n=7; claims=268 | null signal in 4/7 sources | 3 indirect; 4 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_11", "text": "| Immune | n=4; claims=114 | null signal in 2/4 sources | 3 indirect; 1 mechanistic | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_12", "text": "| Longevity | n=2; claims=3 | null signal in 2/2 sources | 1 indirect; 1 mechanistic | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_13", "text": "| Deficiency Prevalence | n=1; claims=23 | null signal in 1/1 sources | 1 indirect | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_14", "text": "| Safety and Comorbidity | n=1; claims=22 | null signal in 1/1 sources | 1 review | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_15", "text": "| Skeletal, Fracture, and Bone | n=1; claims=1 | null signal in 1/1 sources | 1 indirect | single-source slice; hypothesis-generating |", "type": "claim"}, {"id": "claim_16", "text": "This evidence brief reports outcome packets as a map of retained evidence rather than as a full journal Results narrative or pooled effect estimate.", "type": "claim"}, {"id": "claim_17", "text": "47 included sources were assigned to this outcome class. Directional coding: negative=1, null=40, positive=2, unclear=4. Directness coding: direct=1, indirect=31, mechanistic=8, review=7.", "type": "claim"}, {"id": "claim_18", "text": "13 included sources were assigned to this outcome class. Directional coding: null=10, positive=2, unclear=1. Directness coding: indirect=6, mechanistic=7.", "type": "claim"}, {"id": "claim_19", "text": "7 included sources were assigned to this outcome class. Directional coding: null=4, unclear=3. Directness coding: indirect=3, review=4.", "type": "claim"}, {"id": "claim_20", "text": "4 included sources were assigned to this outcome class. Directional coding: mixed=1, negative=1, null=2. Directness coding: indirect=3, mechanistic=1.", "type": "claim"}, {"id": "claim_21", "text": "2 included sources were assigned to this outcome class. Directional coding: null=2. Directness coding: indirect=1, mechanistic=1.", "type": "claim"}, {"id": "claim_22", "text": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: indirect=1.", "type": "claim"}, {"id": "claim_23", "text": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: review=1.", "type": "claim"}, {"id": "claim_24", "text": "1 included source were assigned to this outcome class. Directional coding: null=1. Directness coding: indirect=1.", "type": "claim"}, {"id": "claim_25", "text": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence.", "type": "claim"}, {"id": "claim_26", "text": "| Contextual Adjacent Evidence | n=47; claims=1406 | null signal in 40/47 sources | 1 direct; 31 indirect; 8 mechanistic; 7 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_27", "text": "| Immune and Inflammation | n=13; claims=264 | null signal in 10/13 sources | 6 indirect; 7 mechanistic | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_28", "text": "| Cardiometabolic | n=7; claims=268 | null signal in 4/7 sources | 3 indirect; 4 review | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_29", "text": "| Immune | n=4; claims=114 | null signal in 2/4 sources | 3 indirect; 1 mechanistic | limited corpus depth in this outcome class |", "type": "claim"}, {"id": "claim_30", "text": "| Longevity | n=2; claims=3 | null signal in 2/2 sources | 1 indirect; 1 mechanistic | limited corpus depth in this 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