Derivation Web

source_8484445370f6460f

by researka:v2 · 2026-06-06 04:10:44.846598+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Harringtonine Attenuates Extracellular Matrix Degradation, Skin Barrier Dysfunction, and Inflammation in an In Vitro Skin Aging Model",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Repeated application of passive mechanical stress produces selective metabolic and extracellular matrix adaptations in human skeletal muscle but does not prevent disuse-induced atrophy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Role of Extracellular Matrix and Inflammation in the Stratification of Bleeding and Thrombotic Risk of Atrial Fibrillation on Oral Anticoagulant Therapy: Insights from Strat-Af Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
In vitro and in vivo biocompatibility of a porcine cholecystic extracellular matrix (CECM) membrane for tissue regeneration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of extracellular matrix stiffness on efficacy of Dapagliflozin for diabetic cardiomyopathy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Presence of Adipose Tissue in Aortic Valves Influences Inflammation and Extracellular Matrix Composition in Chronic Aortic Regurgitation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix protein 1 binds to connective tissue growth factor against liver fibrosis and ductular reaction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effect of Extracellular Matrix Stiffness on Candesartan Efficacy in Anti-Fibrosis and Antioxidation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Adjusting the stiffness of a cell-free hydrogel system based on tissue-specific extracellular matrix to optimize adipose tissue regeneration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness reduces DNA 6 ma level to facilitate colorectal cancer progression via disrupting P53 binding to CDKN1A promoter,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Vascular–Extracellular Matrix Molecular Program Identifies High-Risk Diffuse Glioma Across Independent Multi-Omics,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Matrix Stiffness-Induced Mechanotransduction of Capillarized Liver Sinusoidal Endothelial Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Matrix Stiffness and TGFβ2 Regulate YAP/TAZ Activity in Human Trabecular Meshwork Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Altered extracellular matrix structure and elevated stiffness in a brain organoid model for disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Efficacy of decellularized extracellular matrix (dECM) for articular cartilage repair in osteoarthritis (OA): a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Extracellular matrix stiffness aggravates urethral stricture through Igfbp3/Smad pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Tissue and extracellular matrix remodeling of the subchondral bone during osteoarthritis of knee joints as revealed by spatial mass spectrometry imaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Matrix Tissue Patch for Pulmonary Artery Repair in Pediatric Cardiac Surgery: A Single-Center Experience,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Matrix–MYCAF Signatures Correlate with Resistance to Neoadjuvant aPD-L1 Immune Checkpoint Inhibition with Durvalumab + Metformin in HPV+ HNSCC,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"3D Printing of Extracellular Matrix‐Based Multicomponent, All‐Natural, Highly Elastic, and Functional Materials toward Vascular Tissue Engineering",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Preservation of the naïve features of mesenchymal stromal cells in vitro: Comparison of cell- and bone-derived decellularized extracellular matrix,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effect of miRNA-218-5p on Proliferation, Migration, Apoptosis and Inflammation of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm and Extracellular Matrix Protein",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
In need of age‐appropriate cardiac models: Impact of cell age on extracellular matrix therapy outcomes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Lysyl-Oxidase Dependent Extracellular Matrix Stiffness in Hodgkin Lymphomas: Mechanical and Topographical Evidence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Tissue response and clinical outcomes after cardiovascular use of porcine small intestinal small intestinal submucosal extracellular matrix: a systematic review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Association of Epicardial Adipose Tissue Adipocytes Hypertrophy with Biomarkers of Low-Grade Inflammation and Extracellular Matrix Remodeling in Patients with Coronary Artery Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Survivin regulates intracellular stiffness and extracellular matrix production in vascular smooth muscle cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Key role for Rac in the early transcriptional response to extracellular matrix stiffness and stiffness-dependent repression of ATF3,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Suppression of METTL3 expression attenuated matrix stiffness-induced vaginal fibroblast-to-myofibroblast differentiation and abnormal modulation of the extracellular matrix in pelvic organ prolapse,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular Matrix Tissue Patch for Aortic Arch Repair in Pediatric Cardiac Surgery: A Single-Center Experience,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness regulates colorectal cancer progression via HSF4,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
CD248 ‐expressing cancer‐associated fibroblasts induce non‐small cell lung cancer metastasis via Hippo pathway‐mediated extracellular matrix stiffness,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Ecliptasaponin A attenuates renal fibrosis by regulating the extracellular matrix of renal tubular cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
An Extracellular Matrix Aging Clock Based on Circulating Matrisome Proteins Predicts Biological Aging and Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Polycystin‐1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1‐Dependent Microfilament Remodeling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Retinal Progenitor Cells Exhibit Cadherin-Dependent Chemotaxis across Transplantable Extracellular Matrix of In Vitro Developmental and Adult Models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness mediates uterine repair via the Rap1a/ARHGAP35/RhoA/F-actin/YAP axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Varying Properties of Extracellular Matrix Grafts Impact Their Durability and Cell Attachment and Proliferation in an In Vitro Chronic Wound Model,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Multi-Step Extracellular Matrix Remodelling and Stiffening in the Development of Idiopathic Pulmonary Fibrosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Vascular smooth muscle cell senescence accelerates medin aggregation via small extracellular vesicle secretion and extracellular matrix reorganization,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Two-dimensional vascularized liver organoid on extracellular matrix with defined stiffness for modeling fibrotic and normal tissues,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness modulates angiogenic properties of the retinal pigment epithelium,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spatio-Temporal Changes of Extracellular Matrix (ECM) Stiffness in the Development of the Leech Hirudo verbana,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Assessment of Extracellular Matrix Fibrous Elements in Male Dermal Aging: A Ten-Year Follow-Up Preliminary Case Study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The Contributions of Extracellular Matrix and Sarcomere Properties to Passive Muscle Stiffness in Cerebral Palsy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Change in p53 nuclear localization in response to extracellular matrix stiffness,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Adjustable extracellular matrix rigidity tumor model for studying stiffness dependent pancreatic ductal adenocarcinomas progression and tumor immunosuppression,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Tibialis Anterior Muscle Herniation Managed with Ovine Extracellular Matrix Patch: Case Report,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Utilization of a Multi-Tissue Extracellular Matrix in Complex Wound Care in Gaza: A Case Series,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"COMP Is a Biomarker of Cartilage Destruction, Extracellular Matrix and Vascular Remodeling and Tissue Repair",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Versatile Skin-Derived Extracellular Matrix Hydrogel-Based Platform to Investigate the Function of a Mechanically Isolated Adipose Tissue Stromal Vascular Fraction,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix analysis of fibrosis: A step towards tissue engineering for urethral stricture disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Extracellular matrix stiffness activates mechanosensitive signals but limits breast cancer cell spheroid proliferation and invasion,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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