Derivation Web

source_8678a713a0674499

by researka:v2 · 2026-06-27 00:22:52.056797+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "6eba8bfc-d1b3-4094-a4b1-155f1a96a6a0", "sources": [{"directness": "primary", "doi": "10.1002/advs.202511813", "risk_of_bias": "not appraised in public sidecar", "study": "Enhanced Selenium Supplement Extends Lifespan and Delays Multi‐Organs Aging by Regulating the Sik1 Pathway Through Maintaining Calcium Homeostasis"}, {"directness": "primary", "doi": "10.1007/s11357-024-01276-z", "risk_of_bias": "not appraised in public sidecar", "study": "Developmental disruption of the mitochondrial fission gene drp-1 extends the longevity of daf-2 insulin/IGF-1 receptor mutant"}, {"directness": "primary", "doi": "10.1111/acel.70418", "risk_of_bias": "not appraised in public sidecar", "study": "Host Oxidative Response Capacity Determines Longevity Outcomes of Microbial Interventions"}, {"directness": "primary", "doi": "10.1242/dmm.052184", "risk_of_bias": "not appraised in public sidecar", "study": "Decanoic acid extends lifespan and modulates metabolism in models of PLA2G6 -associated neurodegeneration"}, {"directness": "primary", "doi": "10.3390/cells13171470", "risk_of_bias": "not appraised in public sidecar", "study": "Curcumin Inhibits TORC1 and Prolongs the Lifespan of Cells with Mitochondrial Dysfunction"}, {"directness": "primary", "doi": "10.1007/s10522-025-10278-z", "risk_of_bias": "not appraised in public sidecar", "study": "Bridging expectations and science: a roadmap for the future of longevity interventions"}, {"directness": "primary", "doi": "10.3390/biology14030279", "risk_of_bias": "not appraised in public sidecar", "study": "Mitochondrial Proteome Reveals Metabolic Tuning by Restricted Insulin Signaling to Promote Longevity in Caenorhabditis elegans"}, {"directness": "primary", "doi": "10.5937/jomb0-60849", "risk_of_bias": "not appraised in public sidecar", "study": "Molecular mechanisms of metformin action: From metabolic effects to lifespan extension and healthspan promotion"}, {"directness": "primary", "doi": "10.3390/ijms27062633", "risk_of_bias": "not appraised in public sidecar", "study": "Yeast Chronological Lifespan Model as a Tool for Screening Aging Interventions"}, {"directness": "review-level", "doi": "10.1007/s10522-026-10456-7", "risk_of_bias": "not appraised in public sidecar", "study": "Dendrobium officinale leaf extract extends the mean lifespan in Caenorhabditis elegans via the DAF-16/SOD-3 axis."}, {"directness": "primary", "doi": "10.3389/fgene.2014.00211", "risk_of_bias": "not appraised in public sidecar", "study": "Rec-8 dimorphism affects longevity, stress resistance and X-chromosome nondisjunction in C. elegans , and replicative lifespan in S. cerevisiae"}, {"directness": "primary", "doi": "10.1111/acel.12916", "risk_of_bias": "not appraised in public sidecar", "study": "The exceptional longevity of the naked mole‐rat may be explained by mitochondrial antioxidant defenses"}, {"directness": "primary", "doi": "10.1007/s13524-018-0755-7", "risk_of_bias": "not appraised in public sidecar", "study": "A Cohort Comparison of Lifespan After Age 100 in Denmark and Sweden: Are Only the Oldest Getting Older?"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.1093/gerona/glp012", "risk_of_bias": "not appraised in public sidecar", "study": "Cesari 2009"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Anisimov 2008"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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