Derivation Web

source_871851c15edd4c43

by researka:v2 · 2026-06-03 10:46:29.134858+04:00

{"content_hash": null, "edges": [{"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_1", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_2", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_3", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_4", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_5", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_6", "type": "contains_claim"}, {"from": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "to": "claim_7", "type": "contains_claim"}], "nodes": [{"id": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "title": "Bounded Klotho signal: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48)", "type": "publication"}, {"id": "claim_1", "text": "The direct receipts support a narrow working claim: the higher all-cause mortality persisted even after adjustment for confounders (hazard ratio 4.14, confidence interval 1.29-13.48); HR for tertile three of Klotho was 2.18 (95% CI 0.91-2.23). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "Real tension: the useful signal is narrower than the topic label. The lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.", "type": "claim"}, {"id": "claim_4", "text": "Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?", "type": "claim"}, {"id": "claim_5", "text": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "type": "claim"}, {"id": "claim_6", "text": "`fact_id=187886` (`B_context`) — Klotho concentration increased significantly after chronic exercise training (minimum of 12 weeks) (Hedge' g [95%CI] 1.3 [0.69-1.90]; P < 0.0001) doi=10.1038/s41598-022-22123-1", "type": "claim"}, {"id": "claim_7", "text": "_Within the currently bound receipt bundle, no A_core/B_context opposing fact was selected. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1155/2015/406269", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association between Serum Soluble Klotho Levels and Mortality in Chronic Hemodialysis Patients", "type": "source", "url": null, "year": 2015}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1371/journal.pone.0100688", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Prognostic value and link to atrial fibrillation of soluble Klotho and FGF23 in hemodialysis patients.", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.5414/cn107800", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The association of Klotho gene polymorphism with the mortality of patients on maintenance dialysis.", "type": "source", "url": null, "year": 2013}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s12882-019-1391-1", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Soluble Klotho is associated with mortality and cardiovascular events in hemodialysis", "type": "source", "url": null, "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1097/shk.0b013e3182845445", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Sepsis-induced hypercytokinemia and lymphocyte apoptosis in aging-accelerated Klotho knockout mice.", "type": "source", "url": null, "year": 2013}], "publication_id": "40ce88b3-5626-4801-9327-2ac3ebe3f796", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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