source · application/json
source_87d3cfb97f964302
sha256 a609fa590e24f2e3af3423d157441149497242ae4e700ece1673139dc1da7317
by researka:v2 · 2026-06-25 13:08:48.740199+04:00
{"publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd", "traces": [{"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "Across retrieved fact-level receipts for fisetin, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "Finding: DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "This receipt-backed scoping note has one bounded signal: fisetin shows endpoint-specific favorable signals with context limits across this 5-source primary bundle (2010-2023). Grouped by direction: directionally favorable: 3 receipt(s) | other/mixed: 2 receipt(s). The source facts cover 5 population context(s) and 4 intervention/exposure context(s), so this is a scoping signal about where endpoints diverge, without establishing a causal, clinical, species-translated, or mechanistically integrated claim. The listed effect sizes remain source-specific across endpoints and populations; they are not pooled or averaged. This is a heterogeneous indication/context map, not a unified disease-specific or endpoint-family claim. Concrete source-level examples: IC50 of fisetin 3.4 ± 0.3 μM on senescent cells versus 7.0 ± 0.4 μM on control cells; DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h; Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001);.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "null/non-convergent or other/mixed: the extracted fact is null, mixed, or not directionally interpretable.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "directionally favorable: Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells — DHC and fisetin caused dose-dependent reduction in viability and increase in apoptosis in PC3 cells at 72 h.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "directionally favorable: <p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p> — Only quercetin and fisetin inhibited DENV-2 and DENV-3 infection in the absence or presence of enhancing antibody (>90%, p<0.001); ( mechanistic ablation supports the topic effect; not a comparator outcome)", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "directionally favorable: Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models — Fisetin treatment significantly inhibited the activation of p38 and JNK, but had enhanced effect on ERK1/2. ( mechanistic ablation supports the topic effect; not a comparator outcome)", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "Specific moderators in this bundle are population/indication (HEKa cells (adult human epidermal keratinocytes); Human U937-DC-SIGN macrophages infected with dengue virus serotypes 2 or 3; PC3 human prostate cancer cells; TNF-α stimulated NHEKs; senescent human umbilical vein endothelial cells (HUVECs)), study design/evidence type (primary).", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "The selected receipts group because each carries a fact-level extraction for fisetin; they separate by context (human clinical/observational and other source context) and endpoint, so they are not interchangeable evidence for one pooled claim.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1111/acel.14060", "study": "Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence", "url": "https://doi.org/10.1111/acel.14060"}, {"doi": "10.1080/01635581003605524", "study": "Antiproliferative Mechanisms of the Flavonoids 2,2′-Dihydroxychalcone and Fisetin in Human Prostate Cancer Cells", "url": "https://doi.org/10.1080/01635581003605524"}, {"doi": "10.2147/idr.s210890", "study": "<p>Antiviral and immunomodulatory effects of polyphenols on macrophages infected with dengue virus serotypes 2 and 3 enhanced or not with antibodies</p>", "url": "https://doi.org/10.2147/idr.s210890"}, {"doi": "10.3389/fimmu.2022.1075804", "study": "Dual targeting of mTOR/IL-17A and autophagy by fisetin alleviates psoriasis-like skin inflammation", "url": "https://doi.org/10.3389/fimmu.2022.1075804"}, {"doi": "10.3390/cells8091089", "study": "Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models", "url": "https://doi.org/10.3390/cells8091089"}], "claim": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "claim_id": "claim_10"}]}
metadata
{
"researka_object_type": "publication_sidecar",
"researka_publication_id": "f7aceb24-5650-43e9-8e4f-c8d8c3a376dd",
"researka_submission_id": "f7bfa17f-3070-45e1-be7d-998af175bac4",
"sidecar_name": "citation_traces.json",
"sidecar_url": "https://api.researka.org/publications/f7aceb24-5650-43e9-8e4f-c8d8c3a376dd/sidecars/citation_traces.json"
}