Derivation Web

source_87e8bf47ae614465

by researka:v2 · 2026-06-19 10:16:13.568725+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Nicotinamide adenine dinucleotide metabolism and arterial stiffness after long-term nicotinamide mononucleotide supplementation: a randomized, double-blind, placebo-controlled trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD + -Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients: a randomised, double-blinded, placebo-controlled phase-II trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
SERPINE1 drives ferroptosis in acute respiratory distress syndrome by disrupting mitochondrial NAD + homeostasis and suppressing Sirt3 activity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
ADA 2024,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Anisimov 2008,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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  "researka_submission_id": "4ef1a063-933d-419d-9dfa-694a41e59308",
  "sidecar_name": "evidence_table.csv",
  "sidecar_url": "https://api.researka.org/publications/409d864f-0ec9-426f-a90e-da69e4fd0671/sidecars/evidence_table.csv"
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