Derivation Web

source_89eb965382124074

by researka:v2 · 2026-06-01 09:48:40.828762+04:00

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Boundary receipts add a second constraint: Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82).", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "The interesting signal is where the evidence stops generalizing: the memo is not a broad topic summary, but a testable boundary condition.", "type": "claim"}, {"id": "claim_4", "text": "Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=142261` (`A_core`) — approximately 40% of dementia cases worldwide could be attributable to 12 modifiable risk factors doi=10.1111/joim.13227", "type": "claim"}, {"id": "claim_6", "text": "`fact_id=170989` (`A_core`) — Globally, 61·0% (59·6–62·4) of deaths were attributed to the GBD 2017 risk factors. doi=10.1016/s0140-6736(19)31429-1", "type": "claim"}, {"id": "claim_7", "text": "`fact_id=177576` (`A_core`) — up to 90% of strokes might be prevented by addressing and treating ten modifiable stroke risk factors, half of which are related to lifestyle modifications. doi=10.3390/medicina60030504", "type": "claim"}, {"id": "claim_8", "text": "`fact_id=93195` (`A_core`) — 45.1% of cancer deaths (265,150 of 587,521 deaths) were attributable to evaluated risk factors. doi=10.3322/caac.21440", "type": "claim"}, {"id": "claim_9", "text": "`fact_id=93194` (`A_core`) — an estimated 42.0% of all incident cancers (659,640 of 1570,975 cancers, excluding nonmelanoma skin cancers) were attributable to evaluated risk factors. doi=10.3322/caac.21440", "type": "claim"}, {"id": "claim_10", "text": "`fact_id=98930` (`A_core`) — Prevalence of SCD increased from 3.9% among adults with no risk factors to 25.0% among those with four or more risk factors. doi=10.15585/mmwr.mm7120a2", "type": "claim"}, {"id": "claim_11", "text": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "type": "claim"}, {"id": "claim_12", "text": "`fact_id=143088` (`B_context`) — Models with all Quanterix plasma analytes along with risk factors most often provided the best discrimination among amyloid PET stages (C = 0.78-0.82) doi=10.1093/brain/awad042", "type": "claim"}, {"id": "claim_13", "text": "`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) doi=10.1093/brain/awad042", "type": "claim"}, {"id": "claim_14", "text": "`fact_id=143092` (`B_context`) — Lilly p-tau217 did not improve over a model with all Quanterix plasma analytes and risk factors (C = 0.85 versus 0.83) Source: Predicting amyloid PET and tau PET stages with plasma biomarkers", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/joim.13227", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "How can dementia and disability be prevented in older adults: where are we today and where are we going?", "type": "source", "url": null, "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1016/s0140-6736(19)31429-1", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))", "type": "source", "url": null, "year": 2019}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3390/medicina60030504", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Updated Perspectives on Lifestyle Interventions as Secondary Stroke Prevention Measures: A Narrative Review", "type": "source", "url": null, "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3322/caac.21440", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States", "type": "source", "url": null, "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.15585/mmwr.mm7120a2", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged ≥45 Years — United States, 2019", "type": "source", "url": null, "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1093/brain/awad042", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Predicting amyloid PET and tau PET stages with plasma biomarkers", "type": "source", "url": null, "year": 2023}], "publication_id": "55517e8f-0869-4695-bf27-5ef15eac8e31", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 6, "included": 6, "included_or_retained": 6, "screened": 6, "wording": "6 candidate receipts retained after source retrieval, deduplication, and topic filtering. 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