Derivation Web

source_8aa555f38e5f44a9

by researka:v2 · 2026-05-26 17:22:39.916979+04:00

{"content_hash": null, "edges": [{"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_1", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_2", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_3", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_4", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_5", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_6", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_7", "type": "contains_claim"}, {"from": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "to": "claim_8", "type": "contains_claim"}], "nodes": [{"id": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "title": "Exercise: single-source lead signal with broader context receipts", "type": "publication"}, {"id": "claim_1", "text": "The direct receipts support a narrow working claim: Compared with control, exercise alone reduced hs-CRP [-30.2%; 95% CI, -50.3, -1.0]; exercise alone reduced hs-CRP and IL6 (-30.9%; 95% CI, -47.3, -9.5). The context receipts provide source breadth and boundary checks, not independent confirmation of the lead claim.", "type": "claim"}, {"id": "claim_2", "text": "The useful signal is narrower than the topic label: the lead receipts support the core claim, while the added A/B context receipts define where that claim may generalize, fail, or need a separate extraction.", "type": "claim"}, {"id": "claim_3", "text": "`fact_id=12572` (`A_core`) — Mixed-muscle protein fractional synthetic rate increased by 42% at 3 h postexercise and 69% at 24 h postexercise in CON. DOI `10.1152/ajpendo.00600.2013`", "type": "claim"}, {"id": "claim_4", "text": "`fact_id=12544` (`A_core`) — Mortality risk was 11% lower (hazard ratio, 0.89; 95% confidence interval, 0.86-0.93; P<0.001) for every 1-MET increase in exercise capacity. DOI `10.1161/hypertensionaha.114.03510`", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=30392` (`A_core`) — IGF-I/IGFBP-3 ratio increased significantly in the diet + exercise group (+5.4%, P < 0.01) compared with control. DOI `10.1158/1055-9965.epi-13-0337`", "type": "claim"}, {"id": "claim_6", "text": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "type": "claim"}, {"id": "claim_7", "text": "Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.", "type": "claim"}, {"id": "claim_8", "text": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1940-6207.capr-20-0188", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of Exercise or Metformin on Biomarkers of Inflammation in Breast and Colorectal Cancer: A Randomized Trial", "type": "source", "url": null, "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1152/ajpendo.00600.2013", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Activation of mTORC1 signaling and protein synthesis in human muscle following blood flow restriction exercise is inhibited by rapamycin", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/0008-5472.can-16-3125", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise-Induced Catecholamines Activate the Hippo Tumor Suppressor Pathway to Reduce Risks of Breast Cancer Development", "type": "source", "url": null, "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1161/hypertensionaha.114.03510", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Exercise Capacity and All-Cause Mortality in Male Veterans With Hypertension Aged ≥70 Years", "type": "source", "url": null, "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1055-9965.epi-13-0337", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effects of Dietary Weight Loss and Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Protein-3 in Postmenopausal Women: A Randomized Controlled Trial", "type": "source", "url": null, "year": 2013}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Topic:** `exercise`", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Author:** Dom Lynch", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**ORCID:** _not configured_", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Version:** 1.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**License:** CC BY-NC 4.0", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Canonical URL:** _not assigned_", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Suggested citation:** Dom Lynch. (2026). Exercise: single-source lead signal with broader context receipts. ReseaRka Evidence Index. Version 1.0.", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Run bundle SHA-256:** `fe487b28cd8297287f8c8def5605a5aac25b0a1723c07436f22dfdaea7dc6374`", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Memo SHA-256:** `12c36db3312628e59f58153f26a3a4e818cb983d57e130624eff79bc4b43b487`", "type": "source", "url": null, "year": null}, {"comparator": "not extracted", "directness": "citation", "doi": null, "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "**Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "type": "source", "url": null, "year": null}], "publication_id": "d2507e5a-e8e6-4a30-aa39-33d2478faccc", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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