Derivation Web

source_8bb515b12f0d4309

by researka:v2 · 2026-06-14 01:32:19.902634+04:00

{"content_hash": null, "edges": [{"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_1", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_2", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_3", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_4", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_5", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_6", "type": "contains_claim"}, {"from": "62637e62-c4f7-4093-85a4-d608a73edbf5", "to": "claim_7", "type": "contains_claim"}], "nodes": [{"id": "62637e62-c4f7-4093-85a4-d608a73edbf5", "title": "Rapamycin extends lifespan / reduces mortality in mice across diverse stocks, ages, and dosing regimens", "type": "publication"}, {"id": "claim_1", "text": "Across 5 independently cited sources, the evidence converges on one bounded claim: rapamycin extends lifespan / reduces mortality in mice across diverse stocks, ages, and dosing regimens. Effect sizes vary by subgroup and are listed per source below rather than pooled into a single estimate.", "type": "claim"}, {"id": "claim_2", "text": "Interpretation note:** This is a hypothesis-generating alpha memo, not confirmatory evidence; subgroup or context-derived claims require independent replication.", "type": "claim"}, {"id": "claim_3", "text": "Real tension: the interesting signal is where the evidence stops generalizing — the memo is not a broad topic summary but a testable boundary condition.", "type": "claim"}, {"id": "claim_4", "text": "Bounded research question:** Does the cited receipt bundle still support this bounded claim when population, endpoint, comparator, and time window are aligned?", "type": "claim"}, {"id": "claim_5", "text": "`fact_id=166319` (`A_core`) — Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive of an added benefit. doi=10.1111/acel.12496", "type": "claim"}, {"id": "claim_6", "text": "_Boundary evidence only; these receipts broaden source context but do not independently prove the lead claim._", "type": "claim"}, {"id": "claim_7", "text": "_No direct opposing receipt was selected by this run. Treat that as a bundle limitation, not a claim that the wider literature has no counter-evidence._", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7759/cureus.98514", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/41497909/", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.7554/eLife.16351", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27549339/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12496", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27312235/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12194", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/24472261/", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/nature08221", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/19587680/", "year": 2009}], "publication_id": "62637e62-c4f7-4093-85a4-d608a73edbf5", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "62637e62-c4f7-4093-85a4-d608a73edbf5",
  "researka_submission_id": "27f60a7b-7f92-424c-bb44-65d749454a16",
  "sidecar_name": "claim_graph.json",
  "sidecar_url": "https://api.researka.org/publications/62637e62-c4f7-4093-85a4-d608a73edbf5/sidecars/claim_graph.json"
}