Derivation Web

source_8be5e0e763524b28

by researka:v2 · 2026-06-24 21:32:59.715104+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Doxycycline Attenuated Ethanol-Induced Inflammaging in Endothelial Cells: Implications in Alcohol-Mediated Vascular Diseases,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Radiotherapy and inflammaging: the influence of prostate cancer radiotherapy on systemic inflammation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Morin and Morin Semicarbazone Combined with Fucoxanthin Have Potential Anti-Inflammaging Effects Through Modulation of Nrf2/HO-1 System in UVB-Exposed HaCaT Keratinocytes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Neutrophil-to-lymphocyte ratio as a sex-specific predictor of short-term mortality in hospitalised older adults with COVID-19: a pragmatic biomarker of inflammaging in acute vulnerability,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"New insights into the association between cardiometabolic index with metabolic profile, nutritional status, and inflammaging in older adults",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Exoproteome of calorie-restricted humans identifies complement deactivation as an immunometabolic checkpoint reducing inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bottom-up engineering of the nucleus pulposus using a photocrosslinkable decellularized matrix hydrogel attenuates inflammaging and enhances microtissue-mediated regeneration,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Hematopoietic progenitor cell liabilities and alarmins S100A8/A9‐related inflammaging associate with frailty and predict poor cardiovascular outcomes in older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The alteration of bile acids and gut microbiota is associated with intestinal barrier dysfunction and inflammaging in human,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Programmed PPAR-α downregulation induces inflammaging by suppressing fatty acid catabolism in monocytes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Diet and Exercise Interventions in Pediatric Cancer Survivors and Effects on Cardiometabolic Disease Risk and Inflammaging Biomarkers: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Probiotic-Reduced Inflammaging in Older Adults: A Randomized, Double-Blind, Placebo-Controlled Trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Cardiac alterations following experimental hip fracture - inflammaging as independent risk factor,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Fasting and calorie restriction modulate age‐associated immunosenescence and inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging and the sex-frailty paradox,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Long-Term Physical Activity Mitigates Inflammaging Progression in Older Adults Amidst the COVID-19 Pandemic,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Gut-heart immuno-metabolic disruption associated with inflammaging and subclinical coronary artery disease in people with HIV on antiretroviral therapy,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Protective effects of Rosa roxburghii Tratt. extract against UVB-induced inflammaging through inhibiting the IL-17 pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Molecular Remodeling of Peritumoral Tissue in Clear Cell Renal Cell Carcinoma: Insights into Inflammaging and Prognostic Markers,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
NRF1-mediated innate immune response drives inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The inflammaging microenvironment induces dysfunctional rewiring of Tfh cell differentiation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spatiotemporal mapping reveals Ccl8 hi macrophages as key drivers of testicular inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Epigenetic silencing of SPHK1-IRF7 axis drives inflammaging in age-related meniscus degeneration via sphingolipid-immune dysregulation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
IL-34 Downregulation‒Associated M1/M2 Macrophage Imbalance Is Related to Inflammaging in Sun-Exposed Human Skin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Interferon-related inflammaging links epigenetic age acceleration to multimorbidity,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Pomegranate ( Punica granatum L.) Extract Effects on Inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age-related nigral downregulation of the Parkinson’s risk factor FAM49B primes human microglia for inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
2-O-methylmagnolol mitigates the generation of reactive oxidative stress and inflammaging in human gingival epithelial cells and fibroblasts with advanced glycation end products stimulation,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging and Senescence-Driven Extracellular Matrix Remodeling in Age-Associated Cardiovascular Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Targeting EGR1-ATF3 signaling mitigates paravertebral muscle degeneration by regulating cell death and inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Advanced glycation end products induce inflammaging in periodontal ligament fibroblasts through RAGE/AKT/mTOR/glycolysis pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Effects of 2-year cocoa extract supplementation on inflammaging biomarkers in older US adults: findings from the COcoa Supplement and Multivitamin Outcomes Study randomised clinical trial.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Balneotherapy as a potential immunomodulator in inflammaging.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Identification of crucial inflammaging related risk factors in multiple sclerosis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Clonal haematopoiesis in chronic lymphocytic leukaemia: Biology, inflammaging and clinical implications in the era of targeted therapy",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Inflammaging in periodontal, periapical, and malignancy-associated disease: drivers of alveolar bone loss and repair",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Corylin ameliorates inflammaging and pyroptosis in diabetic periodontitis: A preliminary in vitro study,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Bridging aging and colorectal cancer: synergistic roles of inflammaging and immunosenescence,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging and the role of micronutrients as immunomodulators: a pathway to healthy aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"DNA methylation clocks struggle to distinguish inflammaging from healthy aging, but feature rectification improves coherence and enhances detection of inflammaging",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Photinia glabra -derived exosome-like nanovesicles mitigate skin inflammaging via dual regulation of inflammatory signaling and calcium homeostasis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging is minimal among forager-horticulturalists in the Bolivian Amazon.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"The infrapatellar fat pad in inflammaging, knee joint health, and osteoarthritis",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The 3 I’s of immunity and aging: immunosenescence, inflammaging, and immune resilience",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A Novel Strategy to Model Age-Related Cancer for Elucidation of the Role of Th17 Inflammaging in Cancer Progression,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Immunosenescence and Allergy: Molecular and Cellular Links Between Inflammaging, Neuro-Immune Aging, and Response to Biologic Therapies",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging and Senescence-Associated Secretory Phenotype (SASP) in Psoriasis – A Narrative Review of Potential Mechanisms and Anti-Inflammaging Strategies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Rheumatoid Arthritis and Osteoporosis as Prototypes of Immunosenescence in Osteoimmunology: Molecular Pathways of Inflammaging and Targeted Therapies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inflammaging and Cardiovascular Risk in Old Women,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Pathogenesis and inflammaging in myelodysplastic syndromes,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The effect of the mindfulness-based interventions on inflammaging: Protocol for a systematic review and meta-analysis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Autonomic nervous system imbalance during aging contributes to impair endogenous anti-inflammaging strategies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Contribution of Intestinal Barrier Damage, Microbial Translocation and HIV-1 Infection Status to an Inflammaging Signature",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Anti‐inflammaging effects of human alpha‐1 antitrypsin,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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