Derivation Web · source_8d8e81c6d2fb403e

source · application/json

source_8d8e81c6d2fb403e

sha256 5aacf8b1cc393bcd5fa70ddb11568376253172b94c7c556487d4705b4cd6f1f5

by researka:v2 · 2026-06-27 00:22:43.659165+04:00

{"publication_id": "d8e97ad6-d465-4e84-8231-2402678c670c", "traces": [{"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "This synthesis tests the thesis that evidence for Vascular age is context-dependent, separating outcome-specific signals from broader claims and identifying the evidence gaps that should bound interpretation.", "claim_id": "claim_1"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Evidence-honesty note: 14/15 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_2"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "This paper synthesizes evidence on Vascular age across 15 included source papers and 417 high-confidence extracted claims.", "claim_id": "claim_3"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "The evidence profile contains 1 direct clinical source, 13 adjacent clinical sources, and 1 mechanistic or model-system source, with 14 cross-study disagreements across the evidence base.", "claim_id": "claim_4"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "No single positive outcome class dominates the retained corpus; null signals cluster in the contextual adjacent evidence, cardiometabolic and mechanism outcome classes, and negative signals cluster in no dominant outcome class. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_5"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "The conclusion is that Vascular age should be treated as a bounded geroscience hypothesis: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_6"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Classification criteria: Outcome class assignment follows the primary endpoint or claim role recorded in the manifest, with contextual adjacent evidence separated from cardiometabolic, immune, safety, functional, and other endpoint classes. Directness is coded as direct when the source tests the named exposure or construct in the target population with aging-relevant clinical or hard endpoints; indirect when human evidence uses surrogate or adjacent endpoints; mechanistic when the evidence is preclinical, pathway, or model-based; and review when the source synthesizes rather than directly tests effects. Evidence tier records the same hierarchy before claims are interpreted.", "claim_id": "claim_7"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "This manuscript is reported as a Thin-corpus evidence brief. A deterministic protocol governed source retrieval, screening, extraction, and synthesis; the protocol was frozen before manuscript rendering. The full audit trail is in the supplementary `methods_pack.json` and the timestamped submission directory `synthesis-vascular_age-v06-DAILY-2026-06-26T20-01-58Z-R2`.", "claim_id": "claim_8"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_9"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_10"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, longevity, mechanism, safety and comorbidity); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_11"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_12"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Sheng 2025: outcome=Contextual Adjacent Evidence; 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Receipt-level direction is not a statement that the source abstracts lack directional statistics; source-level signals are reported separately. Representative source-level signals are: Sheng 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic; finding=representative statistic P <0.001; source-level statistic reported; claims=102; Nguyen 2026: outcome=Deficiency Prevalence; direction=unclear; directness=indirect; tier=B2; result=Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated; finding=representative statistic p = 0.047; source-level statistic reported; claims=64; Wang 2024: outcome=Cardiometabolic; direction=unclear; directness=direct; tier=A1; result=Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart; finding=representative statistic p < 0.05; source-level statistic reported; claims=54; Werlang 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=The EVA Study: Early Vascular Aging in Women With History of Preeclampsia; finding=representative statistic P =0.011; source-level statistic reported; claims=29; Luo 2025: outcome=Contextual Adjacent Evidence; direction=unclear; directness=review; tier=B2; result=Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in; finding=representative statistic p = 0.0007; source-level statistic reported; claims=22; Lu 2026: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Estimating Vascular Age to Evaluate the Association Between Aging and Cardiovascular Disease; finding=14 extracted claim(s); receipt-level direction is the coded finding; claims=14; Mian 2023: outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2; result=Arterial Age and Early Vascular Aging, But Not Chronological Age, Are Associated With Faster Thoracic Aortic Aneurysm; finding=representative statistic P =0.001; source-level statistic reported; claims=8; Kakaletsis 2024: outcome=Longevity; direction=unclear; directness=review; tier=B1; result=Advanced vascular aging and outcomes after acute ischemic stroke: a systematic review and meta-analysis.; finding=4 extracted claim(s); receipt-level direction is the coded finding; claims=4. These signals inform the bounded conclusion by separating effect direction from evidence tier/directness; indirect, review-level, mechanistic, or contextual evidence remains hypothesis-generating.", "claim_id": "claim_25"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Sheng 2025: Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic; 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representative statistic P =0.011; source-level statistic reported; outcome=Contextual Adjacent Evidence; direction=unclear; directness=indirect; tier=B2.", "claim_id": "claim_27"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Alanis 2025: Accelerated Vascular Aging as a Possible Mechanism of Troponin I Release in the Absence of Clinically Manifested; representative statistic P =0.762; source-level statistic reported; outcome=Mechanism; direction=null; directness=mechanistic; tier=C1.", "claim_id": "claim_28"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Cardiometabolic: Wang 2024 (Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart; representative statistic p < 0.05; source-level statistic reported; direction=unclear; directness=direct; tier=A1); Rodilla 2026 (Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary; 28 extracted claim(s); receipt-level direction is the coded finding; direction=null; directness=indirect; tier=B2); Azizzadeh 2026 (Prevalence and determinants of vascular aging in Austria – a holistic view: the LEAD study; 16 extracted claim(s); receipt-level direction is the coded finding; direction=null; directness=indirect; tier=B2).", "claim_id": "claim_29"}, {"candidate_sources": [{"directness": "primary", "doi": "10.1161/JAHA.125.042610", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_1", "study": "Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.125.042610"}, {"directness": "primary", "doi": "10.1111/acel.70457", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_2", "study": "Endothelial Sirtuins and Mitochondrial Function Are Associated With Testosterone Status: Implications for Accelerated Vascular Aging in Middle‐Age and Older Men With Low Testosterone", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1111/acel.70457"}, {"directness": "primary", "doi": "10.3390/s24175832", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_3", "study": "Impact of a Precision Intervention for Vascular Health in Middle-Aged and Older Postmenopausal Women Using Polar Heart Rate Sensors: A 24-Week RCT Study Based on the New Compilation of Tai Chi (Bafa Wubu)", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3390/s24175832"}, {"directness": "primary", "doi": "10.1161/JAHA.122.028116", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_4", "study": "The EVA Study: Early Vascular Aging in Women With History of Preeclampsia", "support_kind": "candidate_source_row", "url": "https://doi.org/10.1161/JAHA.122.028116"}, {"directness": "primary", "doi": "10.3389/fpubh.2025.1723100", "effect": "not extracted", "endpoint": "not extracted", "population": "not extracted", "source_id": "source_5", "study": "Vascular age as a key for a team-based approach to manage blood pressure bridging community pharmacists and primary healthcare physicians—The TOGETHER trial", "support_kind": "candidate_source_row", "url": "https://doi.org/10.3389/fpubh.2025.1723100"}], "claim": "Contextual Adjacent Evidence: Sheng 2025 (Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic; representative statistic P <0.001; source-level statistic reported; direction=unclear; directness=indirect; tier=B2); Werlang 2023 (The EVA Study: Early Vascular Aging in Women With History of Preeclampsia; representative statistic P =0.011; source-level statistic reported; direction=unclear; directness=indirect; tier=B2); Luo 2025 (Effects of L-citrulline supplementation and watermelon intake on arterial stiffness and endothelial function in; representative statistic p = 0.0007; source-level statistic reported; direction=unclear; directness=review; tier=B2).", "claim_id": "claim_30"}]}

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