Derivation Web

source_8dc1675664344c75

# Source literature boundary memo

## Research question

Across retrieved fact-level receipts for metformin use, which endpoints show directionally favorable versus null/non-convergent signals, and what matched PICO remains untested?

## Selection criteria

The source-literature fallback selected metformin use because the domain snapshot exposed enough fact-backed, topic-overlapping papers. The fa…