Derivation Web · source_8e69ebfbc5e64325

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source_8e69ebfbc5e64325

sha256 1b5650f998883e7b0c309cd78cc94e30f4c36d41a874125597e572e7b029eb77

by researka:v2 · 2026-06-22 01:14:48.509900+04:00

{"publication_id": "55c23130-2789-4619-9045-518911e27dd1", "traces": [{"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Evidence-honesty note: 36/41 retained sources are coded as null or no extracted directional signal; this corpus is non-supportive for clinical efficacy claims and hypothesis-generating only. Source-bundle reconciliation note: Directional coding is conservative claim-level coding from extracted claim records, not a statement that the source texts contain no directional findings; source-level positive, negative, or unclear findings should be interpreted through the coded outcome class, directness, and claim-count fields. 38/41 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.", "claim_id": "claim_1"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "This paper synthesizes evidence on sirtuin intervention aging effects across 41 accepted source papers and 1394 high-confidence extracted claims.", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The evidence profile contains 3 direct clinical sources, 37 adjacent clinical sources, and 1 mechanistic or model-system source, with 116 cross-study disagreements across the evidence base.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Positive study-level signals are summarized in the contextual adjacent evidence outcome class, null signals in the contextual adjacent evidence, cardiometabolic and deficiency prevalence outcome classes, and negative signals in the muscle function, immune and inflammation outcome classes. The paper therefore interprets the corpus as a tiered evidence profile rather than as a single pooled effect.", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The conclusion is that sirtuin intervention aging effects remains a bounded geroscience case: the retained clinical and mechanistic evidence profile defines the scope for targeted testing, while mixed and null findings limit any unqualified anti-aging claim.", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "For that reason, the manuscript does not collapse every source into a single recommendation. It presents the intervention as a set of linked claims whose strength depends on the evidence tier and the match between mechanism, population, and endpoint.", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "This synthesis evaluates evidence on sirtuin intervention aging effects across 41 included source papers and 1394 high-confidence extracted claims. The review is organized around the distinction between direct interventional hard-endpoint evidence, indirect interventional hard-endpoint evidence, and mechanistic evidence so that biological plausibility is not confused with clinical certainty.", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The corpus contains 3 direct clinical sources, 37 adjacent clinical sources, and 1 mechanistic or model-system source. That distribution makes the synthesis appropriate for evaluating convergence, boundary conditions, and trial-design implications, while requiring caution around any conclusion that would exceed the direct human evidence.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The thesis is: Across 41 curated reference papers, the evidence base for Sirtuin shows a context-dependent profile. Positive signals appear in: contextual other. Negative signals appear in: muscle function, immune. Null findings dominate: contextual other, cardiometabolic. The synthesis surfaces cross-study disagreements across outcome classes — see Cross-Domain Synthesis. The Sirtuin anti-aging case as currently constituted is incomplete: mechanistic plausibility coexists with mixed or sparse human-RCT evidence, and the boundary conditions remain to be established. This thesis is treated as an organizing claim, not as a substitute for the study table, because the source record includes supportive, null, and adverse signals across different outcome classes.", "claim_id": "claim_9"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "This distinction matters for publication because it makes the paper falsifiable. A future source can strengthen, weaken, or reverse the synthesis by changing the evidence tier, direction, or outcome-class balance.", "claim_id": "claim_10"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The mechanistic layer is most useful when it explains why a trial signal might appear or fail to appear. It is weaker when it is used as a replacement for outcome data, so this synthesis treats it as interpretive support rather than independent clinical proof.", "claim_id": "claim_11"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Null findings have a specific role in this evidence model. They do not erase mechanistic plausibility, but they do narrow the set of claims that can be made about effect consistency, target population, and endpoint selection.", "claim_id": "claim_12"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Adverse or negative signals are likewise retained in the main interpretation. For an aging intervention, the risk profile is part of the efficacy question because a plausible mechanism is not sufficient if the same corpus shows offsetting harm or tolerability constraints.", "claim_id": "claim_13"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The evidence base also distinguishes breadth from certainty. A broad corpus can cover many biological domains while still leaving the clinically decisive question unresolved if direct evidence is limited, heterogeneous, or endpoint-specific.", "claim_id": "claim_14"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The background evidence for sirtuin intervention aging effects is heterogeneous rather than uniformly confirmatory. Direct clinical sources such as Werida 2023, Daneshi-Maskooni 2017, Bo 2018 are interpreted separately from mechanistic studies such as Krekora 2026, because these evidence roles answer different questions about aging biology and clinical translation.", "claim_id": "claim_15"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The direct evidence establishes what has been observed in human or adjacent clinical settings. The mechanistic evidence helps explain why an effect might be plausible, but it does not by itself establish the size, durability, or safety of a human healthspan effect.", "claim_id": "claim_16"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Across the retained sources, positive signals cluster around the contextual adjacent evidence outcome class; null signals around the contextual adjacent evidence, cardiometabolic and deficiency prevalence outcome classes; and negative or adverse signals around the muscle function, immune and inflammation outcome classes. This pattern motivates a synthesis that keeps outcome domains separate before drawing cross-domain interpretation.", "claim_id": "claim_17"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The study-level structure also prevents selective emphasis. Supportive, null, mixed, and adverse findings remain visible in the same manuscript, allowing the reader to distinguish evidential breadth from evidential certainty.", "claim_id": "claim_18"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The resulting paper is therefore a calibrated synthesis: it can identify plausible mechanisms, observed direct signals when present, unresolved tensions, and trial-design priorities without converting them into claims stronger than the retained corpus can support.", "claim_id": "claim_19"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "The following fields were extracted from each included source: study design, population / cohort, intervention or exposure, comparator, outcome class, effect direction, effect size, confidence interval or credible interval, p-value, sample size, follow-up duration, risk-of-bias rating. Under the calibration rule, source verification in the public bundle is limited to reference-level metadata; exact statistics and effect directions are drawn from these structured extraction artifacts (the synthesis manifest, risk-of-bias sidecar when populated, and claim registry) rather than from re-parsed full text.", "claim_id": "claim_20"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Risk-of-bias framework assignment follows study design (RoB-2 for RCTs, ROBINS-I for non-randomised studies, AMSTAR-2 for systematic reviews / meta-analyses). Public appraisal claims are limited to populated `risk_of_bias.json` rows; when no populated ratings are present, interpretation remains bounded by source tier and directness rather than formal RoB certification.", "claim_id": "claim_21"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Evidence-tension synthesis: claims grouped by outcome class (cardiometabolic, contextual adjacent evidence, deficiency prevalence, dosing and pharmacokinetics, immune and inflammation, immune and inflammation, longevity, muscle function); within-class agreement, disagreement, and directness gaps surfaced explicitly. Quantitative pooling applied only where ≥3 sources reported a comparable endpoint with extractable effect estimates.", "claim_id": "claim_22"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Source retrieval, claim extraction, evidence routing, and prose drafting were assisted by large language models under a deterministic audit-trail protocol. Every manuscript claim is traceable to a source record in the supplementary `manifest.json`. Final eligibility and interpretation decisions are author-verified.", "claim_id": "claim_23"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Additional corpus sources included animal/preclinical evidence; Nowak-Szwed 2025: outcome=Cardiometabolic; directness=indirect; tier=B2.", "claim_id": "claim_24"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Garcia-Martinez 2023: outcome=Contextual Adjacent Evidence; directness=indirect; tier=B2.", "claim_id": "claim_25"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Additional corpus sources included animal/preclinical evidence; substantive evidence synthesis: The manifest includes 41 retained sources, 3 direct-source row(s), and directional coding across negative=2, null=36, positive=1, unclear=2. Representative source-level signals are: Nowak-Szwed 2025: outcome=Cardiometabolic; direction=unclear; directness=indirect; tier=B2; claims=124; Wu 2022: outcome=Cardiometabolic; direction=unclear; directness=indirect; tier=B2; claims=106; Werida 2023: outcome=Contextual Adjacent Evidence; direction=positive; directness=direct; tier=A1; claims=80; Shi 2025: outcome=Muscle Function; direction=negative; directness=indirect; tier=B2; claims=11; Noureldein 2015: outcome=Immune and Inflammation; direction=negative; directness=review; tier=B1; claims=1; Garcia-Martinez 2023: outcome=Contextual Adjacent Evidence; direction=null; directness=indirect; tier=B2; claims=106; Zhang 2025: outcome=Contextual Adjacent Evidence; direction=null; directness=indirect; tier=B2; claims=82; Nguyen 2026: outcome=Deficiency Prevalence; direction=null; directness=indirect; tier=B2; claims=65. These signals inform the bounded conclusion by separating effect direction from evidence tier/directness; indirect, review-level, mechanistic, or contextual evidence remains hypothesis-generating.", "claim_id": "claim_26"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Additional corpus sources included animal/preclinical evidence; key findings from source synthesis: First, the strongest positive or favorable signals are treated as narrow source-level signals, not broad clinical proof (Nowak-Szwed 2025: outcome=Cardiometabolic; direction=unclear; directness=indirect; tier=B2; claims=124; Wu 2022: outcome=Cardiometabolic; direction=unclear; directness=indirect; tier=B2; claims=106; Werida 2023: outcome=Contextual Adjacent Evidence; direction=positive; directness=direct; tier=A1; claims=80). Second, negative, mixed, unclear, or no-directional-signal rows are given equal interpretive weight (Shi 2025: outcome=Muscle Function; direction=negative; directness=indirect; tier=B2; claims=11; Noureldein 2015: outcome=Immune and Inflammation; direction=negative; directness=review; tier=B1; claims=1; Garcia-Martinez 2023: outcome=Contextual Adjacent Evidence; direction=null; directness=indirect; tier=B2; claims=106). Third, the bounded conclusion follows from the balance of source direction, outcome class, evidence tier, and directness rather than from source count alone.", "claim_id": "claim_27"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "| Evidence domain | Corpus slice | Strongest signal | Directness | Main limitation |", "claim_id": "claim_28"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "| Contextual Adjacent Evidence | n=22; claims=779 | no extracted directional signal in 21/22 sources | 2 direct; 18 indirect; 1 protocol; 1 review | limited corpus depth in this outcome class |", "claim_id": "claim_29"}, {"candidate_sources": [{"doi": "10.1186/s12933-025-03013-y", "study": "Sirtuins and regulatory miRNAs as epigenetic determinants of empagliflozin-mediated recovery after acute myocardial infarction", "url": "https://doi.org/10.1186/s12933-025-03013-y"}, {"doi": "10.3390/ijms24087422", "study": "Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes", "url": "https://doi.org/10.3390/ijms24087422"}, {"doi": "10.1038/s41392-022-01257-8", "study": "The sirtuin family in health and disease", "url": "https://doi.org/10.1038/s41392-022-01257-8"}, {"doi": "10.1021/acsomega.5c03880", "study": "Epigallocatechin-3-Gallate from Green Tea Reduces Vascular Aging and Endothelial Cell Senescence by Modifying Autophagy and Ferroptosis through the Sirtuin 1 Signaling Pathway", "url": "https://doi.org/10.1021/acsomega.5c03880"}, {"doi": "10.1186/s12902-023-01511-2", "study": "Effect of coadministration of omega-3 fatty acids with glimepiride on glycemic control, lipid profile, irisin, and sirtuin-1 in type 2 diabetes mellitus patients: a randomized controlled trial", "url": "https://doi.org/10.1186/s12902-023-01511-2"}], "claim": "Outcome-class note:** Contextual Adjacent Evidence denotes background, boundary-condition, or adjacent-outcome sources. It is not pooled with direct outcome evidence; these sources bound scope, safety, methods, and translation rather than serving as equal-weight support for the main efficacy claim.", "claim_id": "claim_30"}]}

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