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source_8ebfe582295d47b8

sha256 5bf908f6d2177a76b7d1bf9793de81b96af74c0c59ad86977c88e92576eeb7ef

by researka:v2 · 2026-06-28 08:20:34.601685+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "21652f17-8a22-4863-aa37-ec5f4e1a7b90", "sources": [{"directness": "review-level", "doi": "10.1186/s12883-026-04780-1", "risk_of_bias": "not appraised in public sidecar", "study": "Clinical and economic outcomes of therapeutic plasma exchange and intravenous immunoglobulin for treating adults with autoimmune neurological disorders: a systematic review and meta-analysis"}, {"directness": "primary", "doi": "10.1002/alz.12137", "risk_of_bias": "not appraised in public sidecar", "study": "A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study"}, {"directness": "review-level", "doi": "10.3389/fneur.2021.662856", "risk_of_bias": "not appraised in public sidecar", "study": "Therapeutic Plasma Exchange in Myasthenia Gravis: A Systematic Literature Review and Meta-Analysis of Comparative Evidence"}, {"directness": "review-level", "doi": "10.1002/alz.12477", "risk_of_bias": "not appraised in public sidecar", "study": "Neuropsychological, neuropsychiatric, and quality‐of‐life assessments in Alzheimer's disease patients treated with plasma exchange with albumin replacement from the randomized AMBAR study"}, {"directness": "primary", "doi": "10.3390/children12111457", "risk_of_bias": "not appraised in public sidecar", "study": "Complications of Therapeutic Plasma Exchange in Pediatric Neuroimmune Disorders"}, {"directness": "primary", "doi": "10.1002/jca.70128", "risk_of_bias": "not appraised in public sidecar", "study": "Pediatric Therapeutic Plasma Exchange: Characterization of Practice, Epidemiology, and Safety Profile at a Children's Hospital in the United States"}, {"directness": "primary", "doi": "10.3390/jcm15020417", "risk_of_bias": "not appraised in public sidecar", "study": "The Role of Therapeutic Plasma Exchange in the Management of Myeloma-Related Cast Nephropathy: A 10-Year Real-World Cohort Study"}, {"directness": "primary", "doi": "10.1111/acel.70103", "risk_of_bias": "not appraised in public sidecar", "study": "Multi‐Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single‐Blinded Randomized Placebo‐Controlled Therapeutic Plasma Exchange"}, {"directness": "primary", "doi": "10.12669/pjms.42.4.14962", "risk_of_bias": "not appraised in public sidecar", "study": "Assessment of clinical characteristics, treatment responses, relapses, and survival in patients with thrombotic thrombocytopenic purpura undergoing therapeutic plasma exchange: A single-center experience"}, {"directness": "primary", "doi": "10.1002/iid3.70369", "risk_of_bias": "not appraised in public sidecar", "study": "Modulation of Cytokines and Immune Cells by Plasma Exchange in Patients With Certain Autoimmune Neurological Diseases"}, {"directness": "primary", "doi": "10.1002/jca.22008", "risk_of_bias": "not appraised in public sidecar", "study": "Effect on haemostasis of different replacement fluids during therapeutic plasma exchange—A comparative multicentre observational study"}, {"directness": "primary", "doi": "10.1002/jca.22027", "risk_of_bias": "not appraised in public sidecar", "study": "Therapeutic plasma exchange in patients with sepsis: Secondary analysis of a cluster‐randomized controlled trial"}, {"directness": "primary", "doi": "10.1038/s41467-025-57198-7", "risk_of_bias": "not appraised in public sidecar", "study": "Plasma exchange therapy for the post COVID-19 condition: a phase II, double-blind, placebo-controlled, randomized trial"}, {"directness": "primary", "doi": "10.3389/fped.2026.1799535", "risk_of_bias": "not appraised in public sidecar", "study": "Severe autoimmune diffuse alveolar hemorrhage in children; 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adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}]}
metadata
{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "21652f17-8a22-4863-aa37-ec5f4e1a7b90",
  "researka_submission_id": "95050532-6e39-4748-80bf-aaacf1938678",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/21652f17-8a22-4863-aa37-ec5f4e1a7b90/sidecars/risk_of_bias.json"
}

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