Derivation Web

source_8eeffff2145c4fea

by researka:v2 · 2026-06-07 09:05:14.674869+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
Meta-analysis of niacin and NAD metabolite treatment in infectious disease animal studies suggests benefit but requires confirmation in clinically relevant models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"Cardioprotecive Properties of Known Agents in Rat Ischemia-Reperfusion Model Under Clinically Relevant Conditions: Only the NAD Precursor Nicotinamide Riboside Reduces Infarct Size in Presence of Fentanyl, Midazolam and Cangrelor, but Not Propofol",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A systematic review of the therapeutic potential of nicotinamide adenine dinucleotide precursors for cognitive diseases in preclinical rodent models,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Nicotinamide Mononucleotide Restores NAD + Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Nicotinamide riboside and pterostilbene reduces frequency and severity of undesirable symptoms of the menopause transition: an open-label, pilot clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
The differential impact of three different NAD + boosters on circulatory NAD and microbial metabolism in humans,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Trigonelline is an NAD + precursor that improves muscle function during ageing and is reduced in human sarcopenia,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"NAD+-Precursor Supplementation With L-Tryptophan, Nicotinic Acid, and Nicotinamide Does Not Affect Mitochondrial Function or Skeletal Muscle Function in Physically Compromised Older Adults.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
NAD<sup>+</sup> Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Redox therapy for neuropsychiatric disorders: Molecular mechanisms and biomarker development,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Long-term region-specific mitochondrial respiration impairment after perinatal asphyxia is prevented by the NAD⁺ donor nicotinamide riboside: A real-time organotypic metabolic profiling approach.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Unveiling the role of NAD glycohydrolase CD38 in aging and age-related diseases: insights from bibliometric analysis and comprehensive review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Effects of nicotinamide riboside on NAD+ levels, cognition, and symptom recovery in long-COVID: a randomized controlled trial.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD + in healthy middle-aged and older adults,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD + Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Bohannon 1997,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Cruz-Jentoft 2019,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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