Derivation Web

source_9064217071f04e2d

by researka:v2 · 2026-06-03 09:17:56.938204+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6", "sources": [{"directness": "primary", "doi": "10.1038/s41467-023-40734-8", "risk_of_bias": "not appraised in public sidecar", "study": "Mandrioli 2023"}, {"directness": "review-level", "doi": "10.1007/s40520-022-02190-0", "risk_of_bias": "not appraised in public sidecar", "study": "Lin 2022"}, {"directness": "primary", "doi": "10.18632/aging.206235", "risk_of_bias": "not appraised in public sidecar", "study": "Moel 2025"}, {"directness": "primary", "doi": "10.1038/s43587-025-00876-4", "risk_of_bias": "not appraised in public sidecar", "study": "Gkioni 2025"}, {"directness": "primary", "doi": "10.3390/nano14211752", "risk_of_bias": "not appraised in public sidecar", "study": "Zhou 2024"}, {"directness": "primary", "doi": "10.1002/jcsm.70274", "risk_of_bias": "not appraised in public sidecar", "study": "Stanfield 2026"}, {"directness": "primary", "doi": "10.1093/rheumatology/kead333", "risk_of_bias": "not appraised in public sidecar", "study": "Baraf 2023"}, {"directness": "primary", "doi": "10.1038/s41467-022-29714-6", "risk_of_bias": "not appraised in public sidecar", "study": "Ham 2022"}, {"directness": "primary", "doi": "10.1016/j.bioactmat.2022.04.033", "risk_of_bias": "not appraised in public sidecar", "study": "Wang 2022"}, {"directness": "primary", "doi": "10.1093/humrep/dead255", "risk_of_bias": "not appraised in public sidecar", "study": "Rosario 2023"}, {"directness": "primary", "doi": "10.1136/jitc-2024-010649", "risk_of_bias": "not appraised in public sidecar", "study": "Dhakal 2025"}, {"directness": "primary", "doi": "10.7554/eLife.54318", "risk_of_bias": "not appraised in public sidecar", "study": "An 2020"}, {"directness": "primary", "doi": "10.1172/JCI162593", "risk_of_bias": "not appraised in public sidecar", "study": "Appelbaum 2024"}, {"directness": "primary", "doi": "10.1111/acel.13086", "risk_of_bias": "not appraised in public sidecar", "study": "Quarles 2020"}, {"directness": "primary", "doi": "10.1371/journal.pone.0281888", "risk_of_bias": "not appraised in public sidecar", "study": "Ge 2023"}, {"directness": "primary", "doi": "10.1136/jitc-2024-010408", "risk_of_bias": "not appraised in public sidecar", "study": "Withers 2025"}, {"directness": "primary", "doi": "10.1002/prp2.1091", "risk_of_bias": "not appraised in public sidecar", "study": "Szoke 2023"}, {"directness": "primary", "doi": "10.1186/s12967-025-07213-8", "risk_of_bias": "not appraised in public sidecar", "study": "Ruan 2025"}, {"directness": "primary", "doi": "10.1111/acel.70131", "risk_of_bias": "not appraised in public sidecar", "study": "IvimeyCook 2025"}, {"directness": "review-level", "doi": "10.1080/0886022X.2025.2515530", "risk_of_bias": "not appraised in public sidecar", "study": "Tang 2025"}, {"directness": "primary", "doi": "10.18502/ijhoscr.v15i4.7479", "risk_of_bias": "not appraised in public sidecar", "study": "Ashrafi 2021"}, {"directness": "primary", "doi": "10.1186/s12883-024-03596-1", "risk_of_bias": "not appraised in public sidecar", "study": "Svensson 2024"}, {"directness": "review-level", "doi": "10.1186/s13063-024-08490-2", "risk_of_bias": "not appraised in public sidecar", "study": "Stanfield 2024"}, {"directness": "primary", "doi": "10.5114/ceji.2022.118778", "risk_of_bias": "not appraised in public sidecar", "study": "Gao 2022"}, {"directness": "primary", "doi": "10.1186/s13063-022-06634-w", "risk_of_bias": "not appraised in public sidecar", "study": "Tunbridge 2022"}, {"directness": "primary", "doi": "10.1007/s11357-021-00438-7", "risk_of_bias": "not appraised in public sidecar", "study": "Horvath 2021"}, {"directness": "primary", "doi": "10.22074/cellj.2021.7198", "risk_of_bias": "not appraised in public sidecar", "study": "Firat 2021"}, {"directness": "review-level", "doi": "10.1007/s11357-022-00691-4", "risk_of_bias": "not appraised in public sidecar", "study": "Phillips 2022"}, {"directness": "primary", "doi": "10.1007/s11357-020-00274-1", "risk_of_bias": "not appraised in public sidecar", "study": "Selvarani 2020"}, {"directness": "primary", "doi": "10.3389/fragi.2025.1628187", "risk_of_bias": "not appraised in public sidecar", "study": "Roark 2025"}, {"directness": "review-level", "doi": "10.1101/2025.08.25.671822", "risk_of_bias": "not appraised in public sidecar", "study": "Liao 2025"}, {"directness": "primary", "doi": "10.7554/eLife.16351", "risk_of_bias": "not appraised in public sidecar", "study": "Bitto 2016"}, {"directness": "primary", "doi": "10.1186/s12974-018-1247-9", "risk_of_bias": "not appraised in public sidecar", "study": "Drion 2018"}, {"directness": "primary", "doi": "10.1038/s41598-019-44106-5", "risk_of_bias": "not appraised in public sidecar", "study": "Schinaman 2019"}, {"directness": "primary", "doi": "10.1111/acel.12882", "risk_of_bias": "not appraised in public sidecar", "study": "CorreiaMelo 2019"}, {"directness": "review-level", "doi": "10.1007/s11357-019-00113-y", "risk_of_bias": "not appraised in public sidecar", "study": "Chung 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": "10.1001/jama.2010.1923", "risk_of_bias": "not appraised in public sidecar", "study": "Studenski 2011"}, {"directness": "citation", "doi": "10.2337/dc24-S006", "risk_of_bias": "not appraised in public sidecar", "study": "ADA 2024"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "WHO 2000"}, {"directness": "citation", "doi": "10.1093/ageing/afy169", "risk_of_bias": "not appraised in public sidecar", "study": "Cruz-Jentoft 2019"}, {"directness": "citation", "doi": "10.1136/bmj.c332", "risk_of_bias": "not appraised in public sidecar", "study": "Schulz 2010"}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6",
  "researka_submission_id": "5b531a37-a8e4-47cd-b276-14815f69553f",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/1ece772b-d3e4-4ad0-b090-ac7e9ea4a1d6/sidecars/risk_of_bias.json"
}