Derivation Web

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by researka:v2 · 2026-07-19 04:41:40.017073+04:00

# Alpha memo: Creatine Muscle and Training Outcomes in Human Studies

Hypothesis-level alpha signal; not clinical advice.

**Alpha hypothesis:** In creatine muscle strength older adults randomized trial, direct human randomized trial receipts support a bounded positive, negative, and null signal across power, score, and strength; treat it as hypothesis-level until the same population and endpoint are replicated.

**Core signal:**
The direct human receipts are randomized trial evidence for power, score, and strength.
Because the recorded directions are positive, negative, and null, this memo treats the bundle as endpoint-specific evidence rather than a pooled clinical effect.

**Receipt-level synthesis:**
- Publication metadata: source records report `14977662` (2004), 10.1007/s11357-025-01889-y (2025), `https://openalex.org/W2602908870` (2016), and 10.1093/rheumatology/kev088.080 (2015); these are article publication years, not trial dates.
- `14977662`: randomized trial in human; endpoint: power, score, and strength; direction: positive; dose: not stated; duration: not stated. Source title: The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial.
- 10.1007/s11357-025-01889-y - randomized trial in human; endpoint: functional strength independent of muscle mass in physically active older adults; direction: improved; dose: not stated; duration: 6-week intervention. Source title: Combined creatine and HMB co-supplementation improves functional strength independent of muscle mass in physically active older adults: a randomized crossover trial.
- `https://openalex.org/W2602908870`: randomized trial in human; endpoint: composition, function, and mass; direction: negative, null, and positive; dose: not stated; duration: 12 weeks supplementation. Source title: Effects of oral creatine supplementation on body composition and objective physical function in rheumatoid arthritis patients. A randomised controlled trial
- 10.1093/rheumatology/kev088.080 - randomized trial in human; endpoint: body composition and objective physical function in rheumatoid arthritis patients? a randomized controlled trial; direction: improved; dose: not stated; duration: 12 weeks supplementation. Source title: 080. Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial

**Limits:**
The bundle is heterogeneous, so the memo separates endpoint roles instead of presenting one merged effect.
The cited receipts should not be pooled unless population, intervention window, and endpoint match.
A same-endpoint human replication would move this from alpha signal toward claim-level evidence.

**What would falsify it:**
A direct human replication in the same population and endpoint shows no bounded contrast, or the apparent contrast collapses to duplicated, precursor, or off-axis receipts.

**Receipts:**
1. `14977662` The effect of creatine supplementation on strength recovery after anterior cruciate ligament (ACL) reconstruction: a randomized, placebo-controlled, double-blind trial., 2004, The American journal of sports medicine. Source: fullraw:pubmed. ID: 14977662
2. 10.1007/s11357-025-01889-y Combined creatine and HMB co-supplementation improves functional strength independent of muscle mass in physically active older adults: a randomized crossover trial., 2025, GeroScience. Source: fullraw:semantic_scholar. ID: https://doi.org/10.1007/s11357-025-01889-y
3. `https://openalex.org/W2602908870` Effects of oral creatine supplementation on body composition and objective physical function in rheumatoid arthritis patients. A randomised controlled trial, 2016. Source: fullraw:openalex. ID: https://openalex.org/W2602908870
4. 10.1093/rheumatology/kev088.080 080. Can Creatine Supplementation Improve Body Composition and Objective Physical Function in Rheumatoid Arthritis Patients? A Randomized Controlled Trial, 2015. Source: fullraw:openalex. ID: https://doi.org/10.1093/rheumatology/kev088.080

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  "domain_slug": "longevity_research",
  "researka_object_type": "submission",
  "researka_submission_id": "f082fdc8-587e-4fb8-b955-1cf849e0cf06",
  "title": "Creatine Muscle and Training Outcomes in Human Studies"
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