Derivation Web

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**Memo — SGLT2i vs Metformin under Endurance Exercise**

**Alpha (1 sentence):** The same drug class anchor ("antidiabetes agent + exercise") splits by compound — dapagliflozin lets adaptation signal travel, while metformin both impairs adaptation and independently protects muscle from damage — so a single "protection" tag cannot be treated as a benefit on the exercised-muscle endpoint.

**Receipt…