Derivation Web

source_93b6f19c900644c4

by researka:v2 · 2026-06-05 13:58:17.615153+04:00

study,population,intervention_or_exposure,comparator,endpoint,effect,risk_of_bias,directness
"Resveratrol ameliorates mitochondrial biogenesis and reproductive outcomes in women with polycystic ovary syndrome undergoing assisted reproduction: a randomized, triple-blind, placebo-controlled clinical trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Chiisanoside Mediates the Parkin/ZNF746/PGC-1α Axis by Downregulating MiR-181a to Improve Mitochondrial Biogenesis in 6-OHDA-Caused Neurotoxicity Models In Vitro and In Vivo: Suggestions for Prevention of Parkinson’s Disease,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Pentoxifylline Enhances Antioxidative Capability and Promotes Mitochondrial Biogenesis in D-Galactose-Induced Aging Mice by Increasing Nrf2 and PGC-1 α through the cAMP-CREB Pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Nrf2 Activation Attenuates Chronic Constriction Injury-Induced Neuropathic Pain via Induction of PGC-1 α -Mediated Mitochondrial Biogenesis in the Spinal Cord,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Paeoniflorin Alleviates Skeletal Muscle Atrophy in Ovariectomized Mice through the ERα/NRF1 Mitochondrial Biogenesis Pathway,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Elevated Kallistatin Induces Myosteatosis and Exercise Intolerance by Antagonizing AdipoR1‐Mediated AMPK Signalling,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Inhibition of TWEAK/Fn14 Ameliorates Sarcopenic Obesity by Restoring Mitochondrial Biogenesis via the AMPK/SIRT1/PGC-1α Axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Acupuncture modulates the AMPK/PGC-1 signaling pathway to facilitate mitochondrial biogenesis and neural recovery in ischemic stroke rats,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Empagliflozin attenuates doxorubicin-induced cardiotoxicity by activating AMPK/SIRT-1/PGC-1α-mediated mitochondrial biogenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Vitamin A regulates mitochondrial biogenesis and function through p38 MAPK-PGC-1α signaling pathway and alters the muscle fiber composition of sheep,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Oxidative Stress, Inflammation, and Activators of Mitochondrial Biogenesis: Tempol Targets in the Diaphragm Muscle of Exercise Trained- mdx Mice",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Chinese leek-derived extracellular vesicles ameliorate sarcopenia by regulating mitochondrial biogenesis and autophagy via AMPK and maintaining myosin homeostasis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"PGC-1α Methylation, miR-23a, and miR-30e Expression as Biomarkers for Exercise- and Diet-Induced Mitochondrial Biogenesis in Capillary Blood from Healthy Individuals: A Single-Arm Intervention",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Moxibustion delays ovarian aging by regulating mitochondrial biogenesis and improving oocyte quality,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
A balanced formula of essential amino acids promotes brain mitochondrial biogenesis and protects neurons from ischemic insult,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"The effect of royal jelly in oxidative stress, athletic performance, and mitochondrial biogenesis-related gene expression in endurance athletes: study protocol for a double-blind crossover trial",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Cedrol ameliorates inflammatory bowel disease via mitochondrial biogenesis, gut microbiota restoration, and intestinal barrier repair",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Autophagic-active nanosystem for senile bone regeneration by in-situ mitochondrial biogenesis and intercellular transfer,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
MON-623 Insulin Influences Human Lactation and Promotes Mammary Mitochondrial Biogenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Resistance Exercise Improves Glycolipid Metabolism and Mitochondrial Biogenesis in Skeletal Muscle of T2DM Mice via miR-30d-5p/SIRT1/PGC-1α Axis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Tom70-based transcriptional regulation of mitochondrial biogenesis and aging,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Dehydroepiandrosterone Shifts Energy Metabolism to Increase Mitochondrial Biogenesis in Female Fertility with Advancing Age,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Engineering Mitochondrial Biogenesis in iPSC-CMs: CRISPR-Guided Approaches for Advanced Cardiomyocyte Development,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Regulation of mitochondrial biogenesis and energy metabolism in the heart,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
PGC-1α: key regulator of mitochondrial biogenesis and cellular differentiation in metabolic and regenerative tissues,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Multiple stressors, including cold exposure, disrupt growth and intestinal homeostasis via TLR4/p38MAPK/NF-κB and AMPK/SIRT1/PGC-1α pathways in layer chicks.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
PERM1—An Emerging Transcriptional Regulator of Mitochondrial Biogenesis: A Systematic Review,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Aging-Associated Reductions in AMP-Activated Protein Kinase Activity and Mitochondrial Biogenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
LncRNA AW112010 Promotes Mitochondrial Biogenesis and Hair Cell Survival: Implications for Age-Related Hearing Loss,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Branched-chain amino acids, mitochondrial biogenesis, and healthspan: an evolutionary perspective",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Differential Expression of PGC-1α and Metabolic Sensors Suggest Age-Dependent Induction of Mitochondrial Biogenesis in Friedreich Ataxia Fibroblasts,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
"Impaired exercise-induced mitochondrial biogenesis in the obese Zucker rat, despite PGC-1α induction, is due to compromised mitochondrial translation elongation",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
AMPK maintains energy homeostasis and survival in cancer cells via regulating p38/PGC-1 α -mediated mitochondrial biogenesis,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,primary
Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,review-level
"**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
"**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else.",not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen.,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Perera 2006,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation
Ioannidis 2005,not extracted,not extracted,not extracted,not extracted,not extracted,not appraised in public sidecar,citation

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