source · application/json
source_9500ff1c79c14cb6
sha256 ae094e7906e72a3eecce2a4dfa63d23b4a4b1661303a3d89b70e8e73c9f4e12d
by researka:v2 · 2026-06-22 01:25:38.961669+04:00
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They vary across population, comparator, and/or endpoint and are catalogued by source in the Findings Map rather than pooled into one estimate — cross-population aggregation is not claimed. Each row records its own population, comparator, endpoint, and effect, so the spread of the literature and any tensions between findings remain explicit.", "type": "claim"}, {"id": "claim_2", "text": "| Caenorhabditis elegans | control | Metformin causes an 86% increase in S-adenosylmethionine (SAMe) | 2025 doi:10.3390/ph18010055 |", "type": "claim"}, {"id": "claim_3", "text": "| patients with type 2 diabetes mellitus… | baseline | MRI-PDFF decreased significantly with sitagliptin (15.5% ± 5.6% to 11.7% ± 5.0%, P = 0.001… | 2018 doi:10.1002/hep.30320 |", "type": "claim"}, {"id": "claim_4", "text": "| genetically heterogeneous mice (ITP) | rapamycin alone (historical… | Metformin (0.1%) combined with rapamycin (14 ppm) robustly extended lifespan, suggestive o… | 2016 doi:10.1111/acel.12496 |", "type": "claim"}, {"id": "claim_5", "text": "| mice on high-fat diet | without metformin | Clostridium cocleatum (0.10%±0.09%) abundances increased significantly after metformin tre… | 2014 doi:10.1128/aem.01357-14 |", "type": "claim"}, {"id": "claim_6", "text": "| 342 overweight patients with newly dia… | — | this subgroup experienced a 39% (P = 0.010) risk reduction for myocardial infarction | 2011 doi:10.2337/dc10-2361 |", "type": "claim"}, {"id": "claim_7", "text": "| A/J mice treated with tobacco carcinog… | — | Metformin decreased tumor burden by 72%, which correlated with decreased cellular prolifer… | 2010 doi:10.1158/1940-6207.capr-10-0055 |", "type": "claim"}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1007/s12325-025-03256-x", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin: Old Drug, New Therapeutic Potential in the Skin? A Brief Narrative Review.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/40465202/", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/ph18010055", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Gut Microbiota-Related Antihyperglycemic Effect of Metformin", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/39861118/", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.21203/rs.3.rs-5920485/v1", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Selecting Appropriate Clinical Trial Endpoints for Geroscience Trials: A Path Towards Consensus.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/39989956/", "year": 2025}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1016/j.heliyon.2024.e37883", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Gut aging: A wane from the normal to repercussion and gerotherapeutic strategies.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/39381110/", "year": 2024}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.13802", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Intestinal stem cell aging at single‐cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/36864750/", "year": 2023}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.3892/or.2022.8266", "effect": "not extracted", "endpoint": "not extracted", "id": "source_6", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Advances in metformin‑based metabolic therapy for non‑small cell lung cancer (Review)", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/35039878/", "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1038/s41591-022-01803-5", "effect": "not extracted", "endpoint": "not extracted", "id": "source_7", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/35551292/", "year": 2022}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fmed.2021.640785", "effect": "not extracted", "endpoint": "not extracted", "id": "source_8", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/33855034/", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1172/jci.insight.133247", "effect": "not extracted", "endpoint": "not extracted", "id": "source_9", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/32369446/", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3390/biom10091304", "effect": "not extracted", "endpoint": "not extracted", "id": "source_10", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Usefulness of Diagnostic Panels Based on Circulating Adipocytokines/Regulatory Peptides, Renal Function Tests, Insulin Resistance Indicators and Lipid-Carbohydrate Metabolism Parameters in Diagnosis and Prognosis of Type 2 Diabetes Mellitus with Obesity", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/32917052/", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.4269/ajtmh.20-0375", "effect": "not extracted", "endpoint": "not extracted", "id": "source_11", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/32446312/", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fphar.2019.01375", "effect": "not extracted", "endpoint": "not extracted", "id": "source_12", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Availability, Pricing, and Affordability of Essential Diabetes Medicines in 17 Low-, Middle-, and High-Income Countries", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/31824316/", "year": 2019}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/hep.30320", "effect": "not extracted", "endpoint": "not extracted", "id": "source_13", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Liraglutide, Sitagliptin, and Insulin Glargine Added to Metformin: The Effect on Body Weight and Intrahepatic Lipid in Patients With Type 2 Diabetes Mellitus and Nonalcoholic Fatty Liver Disease", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/30341767/", "year": 2018}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1186/s12933-017-0607-6", "effect": "not extracted", "endpoint": "not extracted", "id": "source_14", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The effects of vildagliptin compared with metformin on vascular endothelial function and metabolic parameters: a randomized, controlled trial (Sapporo Athero-Incretin Study 3)", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/29017497/", "year": 2017}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1111/acel.12496", "effect": "not extracted", "endpoint": "not extracted", "id": "source_15", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27312235/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1681/asn.2016030278", "effect": "not extracted", "endpoint": "not extracted", "id": "source_16", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/27539604/", "year": 2016}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1128/aem.01357-14", "effect": "not extracted", "endpoint": "not extracted", "id": "source_17", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Effect of metformin on metabolic improvement and gut microbiota.", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/25038099/", "year": 2014}, {"comparator": "not extracted", "directness": "primary", "doi": "10.2337/dc10-2361", "effect": "not extracted", "endpoint": "not extracted", "id": "source_18", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Use of Metformin in the Setting of Mild-to-Moderate Renal Insufficiency", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/21617112/", "year": 2011}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1158/1940-6207.capr-10-0055", "effect": "not extracted", "endpoint": "not extracted", "id": "source_19", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis", "type": "source", "url": "https://pubmed.ncbi.nlm.nih.gov/20810672/", "year": 2010}], "publication_id": "57cdda93-cf6f-4497-b8fa-c2a05a658c90", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 19, "included": 19, "included_or_retained": 19, "screened": 19, "wording": "19 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}
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