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# Hypothesis-Generating Brief: Low dose naltrexone inflammation — full paper
## Abstract

Evidence-honesty note: 36/39 retained sources are indirect, review-level, adjacent, or mechanistic and are used only to bound interpretation. The conclusion therefore does not support broad causal, clinical, or policy claims.

Low-dose naltrexone, typically administered at 1–6 mg daily rather than the 50–100 …