Derivation Web

source_969215c285a244f6

by researka:v2 · 2026-06-26 07:04:31.868351+04:00

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Single primary-study estimates are separated from pooled review or meta-analytic estimates rather than treated as interchangeable.", "type": "claim"}, {"id": "claim_7", "text": "The selected receipts group because each carries a fact-level extraction for metformin_longevity; they separate by context (human clinical/observational) and endpoint, so they are not interchangeable evidence for one pooled claim.", "type": "claim"}, {"id": "claim_8", "text": "The signal is purely descriptive of effect-direction heterogeneity; it cannot support even a weak causal or comparative-efficacy inference, and pooling across these PICOs would be inappropriate.", "type": "claim"}, {"comparator": "not extracted", "directness": "primary", "doi": "10.3389/fmed.2021.640785", "effect": "not extracted", "endpoint": "not extracted", "id": "source_1", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Association Between Preadmission Metformin Use and Outcomes in Intensive Care Unit Patients With Sepsis and Type 2 Diabetes: A Cohort Study", "type": "source", "url": "https://doi.org/10.3389/fmed.2021.640785", "year": 2021}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1172/jci.insight.133247", "effect": "not extracted", "endpoint": "not extracted", "id": "source_2", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Phase II clinical trial of metformin as a cancer stem cell-targeting agent in ovarian cancer", "type": "source", "url": "https://doi.org/10.1172/jci.insight.133247", "year": 2020}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1016/j.dsx.2020.11.006", "effect": "not extracted", "endpoint": "not extracted", "id": "source_3", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis", "type": "source", "url": "https://doi.org/10.1016/j.dsx.2020.11.006", "year": 2020}, {"comparator": "not extracted", "directness": "primary", "doi": "10.1002/ijc.31783", "effect": "not extracted", "endpoint": "not extracted", "id": "source_4", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Use of metformin and survival of patients with high‐grade glioma", "type": "source", "url": "https://doi.org/10.1002/ijc.31783", "year": 2018}, {"comparator": "not extracted", "directness": "review-level", "doi": "10.1158/1940-6207.capr-13-0424", "effect": "not extracted", "endpoint": "not extracted", "id": "source_5", "intervention_or_exposure": "not extracted", "population": "not extracted", "risk_of_bias": "not appraised in public sidecar", "study": "Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders", "type": "source", "url": "https://doi.org/10.1158/1940-6207.capr-13-0424", "year": 2014}], "publication_id": "62430fb3-2826-496e-a45c-494e9acdb5ba", "screening": {"excluded": 0, "exclusion_reasons": ["No PRISMA full-text exclusion-stage filter was applied."], "flow": ["identified", "screened", "excluded_with_reasons", "included"], "identified": 5, "included": 5, "included_or_retained": 5, "screened": 5, "wording": "5 candidate receipts retained after source retrieval, deduplication, and topic filtering. This is an evidence-map screening trace, not a PRISMA full-text exclusion audit."}}

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