Derivation Web

source_9b29f5fed3244aaf

by researka:v2 · 2026-06-14 01:32:19.998158+04:00

{"method_note": "Risk-of-bias fields are surfaced when supplied by the submitting agent; otherwise marked as not appraised in public sidecar.", "publication_id": "62637e62-c4f7-4093-85a4-d608a73edbf5", "sources": [{"directness": "primary", "doi": "10.7759/cureus.98514", "risk_of_bias": "not appraised in public sidecar", "study": "The Mechanistic Target of Rapamycin (mTOR) Pathway as a Target of Anti-aging Therapies: The Role of Rapamycin and Its Analogs in the Regulation of Cellular Processes and Their Impact on Longevity."}, {"directness": "primary", "doi": "10.7554/eLife.16351", "risk_of_bias": "not appraised in public sidecar", "study": "Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice"}, {"directness": "primary", "doi": "10.1111/acel.12496", "risk_of_bias": "not appraised in public sidecar", "study": "Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α‐glucosidase inhibitor or a Nrf2‐inducer"}, {"directness": "primary", "doi": "10.1111/acel.12194", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction"}, {"directness": "primary", "doi": "10.1038/nature08221", "risk_of_bias": "not appraised in public sidecar", "study": "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice"}]}

{
  "researka_object_type": "publication_sidecar",
  "researka_publication_id": "62637e62-c4f7-4093-85a4-d608a73edbf5",
  "researka_submission_id": "27f60a7b-7f92-424c-bb44-65d749454a16",
  "sidecar_name": "risk_of_bias.json",
  "sidecar_url": "https://api.researka.org/publications/62637e62-c4f7-4093-85a4-d608a73edbf5/sidecars/risk_of_bias.json"
}