Derivation Web

source_a27ef435bdda4ca9

by researka:v2 · 2026-05-24 18:46:15.289940+04:00

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Shorter telomeres are generally associated with higher mortality risk; Telomere length is influenced by genetic factors", "claim_id": "claim_2"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "Real tension: Fact 1 shows genetically determined longer telomere length lowers coronary heart disease risk, while facts 4 and 7 indicate it raises cancer risk, creating a therapeutic dilemma.", "claim_id": "claim_3"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "`fact_id=109012` (`A_core`) — Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) DOI `10.1111/acel.13017`", "claim_id": "claim_4"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "`fact_id=109013` (`A_core`) — but raised risk of cancer (OR = 1.11, 95% CI: 1.06-1.16) DOI `10.1111/acel.13017`", "claim_id": "claim_5"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "_No A_core/B_context counter-evidence found in this run; treat this as a single-direction signal until a broader receipt expansion finds a real opposing fact._", "claim_id": "claim_6"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "Genetically determined longer telomere length was associated with lowered risk of coronary heart disease (CHD; OR = 0.95, 95% CI: 0.92-0.98) _(alpha cues: translation_context)_", "claim_id": "claim_7"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "Suggested citation:** Dom Lynch. (2026). The Telomere Length Paradox: Quantifying Trade-offs Between Cardioprotection and Carcinogenesis Across Subgroups. ReseaRka Evidence Index. Version 1.0.", "claim_id": "claim_8"}, {"candidate_sources": [{"doi": "10.1111/acel.13017", "study": "Telomere length and aging‐related outcomes in humans: A Mendelian randomization study in 261,000 older participants", "url": null}, {"doi": "10.1158/1055-9965.epi-16-0968", "study": "The Association of Telomere Length in Peripheral Blood Cells with Cancer Risk: A Systematic Review and Meta-analysis of Prospective Studies", "url": null}, {"doi": null, "study": "**Topic:** `telomere`", "url": null}, {"doi": null, "study": "**Author:** Dom Lynch", "url": null}, {"doi": null, "study": "**ORCID:** _not configured_", "url": null}], "claim": "Priority note:** This memo records the first published framing, source bundle, and evidence receipts for this run. Reuse should cite the canonical version.", "claim_id": "claim_9"}]}

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