Derivation Web

source_a478ff3c82ea44ac

by researka:v2 · 2026-06-26 06:30:00.348768+04:00

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TORC1 Inhibition with RTB101 as a Potential Pan-Antiviral Immunotherapy to Decrease the Incidence of Respiratory Tract Infections Due to Multiple Respiratory Viruses in Older Adults"}, {"directness": "review-level", "doi": "10.1056/nejmoa1109653", "risk_of_bias": "not appraised in public sidecar", "study": "Everolimus in Postmenopausal Hormone-Receptor–Positive Advanced Breast Cancer"}, {"directness": "review-level", "doi": "10.1200/jco.2005.23.16_suppl.7104", "risk_of_bias": "not appraised in public sidecar", "study": "Phase I/II trial of gefitinib and RAD001 (everolimus) in patients (pts) with advanced non-small cell lung cancer (NSCLC)"}, {"directness": "review-level", "doi": "10.1200/jco.2012.30.15_suppl.556", "risk_of_bias": "not appraised in public sidecar", "study": "Everolimus (RAD) as treatment in breast cancer patients with bone metastases only: Results of the phase II RADAR study."}, {"directness": "primary", "doi": "10.1158/0008-5472.can-06-4490", "risk_of_bias": "not appraised in public sidecar", "study": "RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer"}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "A Study to Determine the Safety and Effectiveness of RAD001 (Everolimus) in Patients With Lymphangioleiomyomatosis"}, {"directness": "primary", "doi": "10.1159/000496984", "risk_of_bias": "not appraised in public sidecar", "study": "Everolimus and Bevacizumab in the Management of Recurrent, Progressive Intracranial NF2 Mutated Meningioma"}, {"directness": "review-level", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women"}, {"directness": "review-level", "doi": "10.1200/jco.2014.58.3401", "risk_of_bias": "not appraised in public sidecar", "study": "Phase II Study of Everolimus and Letrozole in Patients With Recurrent Endometrial Carcinoma"}, {"directness": "review-level", "doi": "10.3109/10428190903486220", "risk_of_bias": "not appraised in public sidecar", "study": "Experience with everolimus (RAD001), an oral mammalian target of rapamycin inhibitor, in patients with systemic mastocytosis"}, {"directness": "review-level", "doi": "10.3233/kca-170020", "risk_of_bias": "not appraised in public sidecar", "study": "Fourth-Line Therapy in Metastatic Renal Cell Carcinoma (mRCC): Results from the International mRCC Database Consortium (IMDC)"}, {"directness": "review-level", "doi": "10.1182/blood.v110.11.121.121", "risk_of_bias": "not appraised in public sidecar", "study": "A Phase II Trial of the Oral mTOR Inhibitor Everolimus (RAD001) in Relapsed Aggressive Non-Hodgkin Lymphoma (NHL)."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Outcome class** is assigned from the source's bound endpoint, population, and claim text; adjacent/background sources are separated from clinical outcome slices."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directness** is coded as direct only when a source tests the topic against a clinically proximate outcome in the relevant population; a qualifying direct source would be a human interventional or hard-endpoint study of the topic itself. Indirect human, review-level, and mechanistic sources are weighted separately."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Directional signal** is counted within the assigned outcome class only. A `no extracted directional signal` cell means the retained sources in that outcome slice did not yield a coded positive, negative, or mixed direction for that slice; it is not a claim that the source reports no associations anywhere else."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "**Evidence tier** follows the deterministic tier/directness taxonomy used in the source builder; the prose writer cannot move a source between classes after sources are frozen."}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "LB TORC Inhibition 2019"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Everolimus and or Exercise to Prevent 2026"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Study to Determine the Safety 2012"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Everolimus Aging Study 2026"}, {"directness": "citation", "doi": null, "risk_of_bias": "not appraised in public sidecar", "study": "Resistance Training and Rapamycin n.d."}, {"directness": "citation", "doi": "10.1371/journal.pmed.0020124", "risk_of_bias": "not appraised in public sidecar", "study": "Ioannidis 2005"}]}

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