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# Alpha memo: Cold Water Immersion: Endpoint Heterogeneity in Acute Proxy vs Chronic Training Adaptation Hypothesis-level alpha signal; not clinical advice. ## Core signal The strongest direct human evidence (10.1123/ijspp.2019-0965) is a randomized trial reporting a large negative effect of cooling on muscle mass (g = 1.20; significant condition × time, P = .01, F = 10.00), alongside non-signifi…
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